144367-16-8 Usage
Description
6,7-Dihydroxyswainsonine is an analog of Swainsonine, a plant alkaloid that serves as an inhibitor of α-mannosidase. It is an off-white crystalline solid with the potential for various applications in the pharmaceutical and biotechnology industries due to its ability to inhibit α-mannosidase with 20-to 100-fold less activity compared to Swainsonine.
Uses
Used in Pharmaceutical Industry:
6,7-Dihydroxyswainsonine is used as a pharmaceutical compound for its ability to inhibit α-mannosidase, which is a target for drug development in anti-tumor therapies. By inhibiting this enzyme, it can potentially disrupt the glycosylation process in cancer cells, thereby affecting their growth and proliferation.
Used in Biotechnology Industry:
6,7-Dihydroxyswainsonine is used as a research tool in the biotechnology industry to study the role of α-mannosidase in various biological processes. Its lower activity compared to Swainsonine makes it a valuable compound for investigating the enzyme's function and its potential as a therapeutic target.
Used in Drug Development:
6,7-Dihydroxyswainsonine is used as a lead compound in the development of new drugs targeting α-mannosidase for the treatment of cancer and other diseases. Its structural similarity to Swainsonine and its ability to inhibit the enzyme with reduced activity make it a promising candidate for further optimization and development into a more potent and selective inhibitor.
Used in Drug Delivery Systems:
Similar to Gallotannin, 6,7-Dihydroxyswainsonine could potentially be incorporated into novel drug delivery systems to enhance its applications and efficacy against cancer cells. Various organic and metallic nanoparticles could be employed as carriers for 6,7-Dihydroxyswainsonine delivery, aiming to improve its delivery, bioavailability, and therapeutic outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 144367-16-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,3,6 and 7 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 144367-16:
(8*1)+(7*4)+(6*4)+(5*3)+(4*6)+(3*7)+(2*1)+(1*6)=128
128 % 10 = 8
So 144367-16-8 is a valid CAS Registry Number.
144367-16-8Relevant articles and documents
Total asymmetric syntheses of 1,5-dideoxy-1,5-iminooctitols and 1,2,6,7,8-pentahydroxyindolizidines
Chen,Vogel
, p. 2487 - 2496 (2007/10/02)
(1R,4R,5S,6S,7S)-4-exo-[(1'S,2'R)-1'-Hydroxy-2',3'-(isopropylidenediox y)propyl]-6-exo,7-exo-(isopropylidenedioxy)-2,8-dioxabicyclo[3.2.1]oct an-3-one ((+)-5) and its diastereomer (1S,4S,5R,6R,7R)-(1'R,2'R)-(-)-30 derived from (R)-2,3-O-isopropylideneglyc
