144372-49-6

Basic information

• Product Name: (2R)-N-ethoxycarbonyl-2-phenyl-2-hydroxyethylamine
• Synonyms: (2R)-N-ethoxycarbonyl-2-phenyl-2-hydroxyethylamine
• CAS NO: 144372-49-6
• Molecular Weight: 209.245
• Mol File: 144372-49-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2R)-N-ethoxycarbonyl-2-phenyl-2-hydroxyethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-N-ethoxycarbonyl-2-phenyl-2-hydroxyethylamine(144372-49-6)
• EPA Substance Registry System: (2R)-N-ethoxycarbonyl-2-phenyl-2-hydroxyethylamine(144372-49-6)

Safety Data

• Hazardous Substances Data: 144372-49-6(Hazardous Substances Data)

Upstream product

• 59840-70-9 α-(ethoxycarbonylamino)acetophenone 
• 109355-73-9 ethyl 2-hydroxy-2-phenylethylcarbamate 
• 100-42-5 styrene 
• 51-79-6 urethane 
• 5468-37-1 2-aminoacetophenone hydrochloride 

Downstream Products

• 56613-81-1 (S)-2-Amino-1-phenyl-1-ethanol 
• 2549-14-6 (R)-2-Amino-1-phenylethanol 

Relevant articles and documents

Asymmetric aminohydroxylation of substituted styrenes using t-butyl carbamate

A variety of substituted styrenes have been aminohydroxylated using t- butyl carbamate to give either enantiomer of highly enantiomerically enriched N-Boc protected amino alcohols in good yields. Better levels of regioselectivity were observed with (DHQ)2PHAL than with (DHQD)2PH. AL even though the enantioselectivities observed were comparable. One of the amino alcohol products was converted into a novel chiral diamine.

Baker's Yeast Reduction of α-(Acylamino)acetophenones and Lipase Catalyzed Resolution of 2-Acylamino-1-arylethanols

Enzymatic reduction of α-acylaminoacetophenones with fermenting baker's yeast afforded optically active (R)-2-acylamino-1-arylethanols.Furthermore, lipase-catalyzed resolution of the 2-acylamino-1-arylethanols using vinyl acetate as an acyl donor resulted in the formation of (S)-1-acetoxy-2-acylamino-1-arylethanols and (R)-2-acylamino-1-arylethanols.