1443788-15-5Relevant articles and documents
Co(II)-Catalyzed Desilylative Annulation of Benzamides and Acrylamides with Alkynylsilanes: Access to 3-Methyleneisoindolin-1-one and 5-Methylene-1 H -pyrrol-2(5 H)-one Derivatives
Shen, Liang
, p. 1969 - 1980 (2020)
The cobalt-catalyzed desilylative annulation of C(sp 2)-H bonds of benzamides and acrylamides with alkynylsilanes assisted by an 8-aminoquinolyl directing group is reported. A variety of benzamides and acrylamides were compatible in this protocol to construct various 3-methyleneisoindolin-1-one and 5-methylene-1 H -pyrrol-2(5 H)-one derivatives with Z -configuration selectivity in moderate to high yields.
Cupraelectro-Catalyzed Alkyne Annulation: Evidence for Distinct C-H Alkynylation and Decarboxylative C-H/C-C Manifolds
Tian, Cong,Dhawa, Uttam,Scheremetjew, Alexej,Ackermann, Lutz
, p. 7690 - 7696 (2019/08/20)
Synthetically meaningful isoindolones were accessed by cupraelectro-catalyzed C-H activation with electricity as terminal oxidant. Thus, a versatile, inexpensive, and nontoxic Cu(OAc)2 catalyst enabled broadly applicable C-H/N-H functionalizations on electron-rich and electron-deficient benzamides with distinct functional group tolerance and resource-economy. Detailed mechanistic studies provided strong support for a C-H alkynylation mechanism through fast C-H metalation, which likewise set the stage for cupraelectro-catalyzed C-H/C-C functionalizations in a decarboxylative fashion.
Iron-catalyzed ortho -allylation of aromatic carboxamides with allyl ethers
Asako, Sobi,Ilies, Laurean,Nakamura, Eiichi
supporting information, p. 17755 - 17757 (2014/01/06)
Arenes possessing an N-(quinolin-8-yl)amide directing group are ortho-allylated with allyl phenyl ether in the presence of an iron/diphosphine catalyst and an organometallic base at 50-70 C. The reaction proceeds via fast iron-catalyzed C-H activation, fo
