1443788-20-2

Basic information

• Product Name: N-(5-chloroquinolin-8-yl)-benzamide
• Synonyms: N-(5-chloroquinolin-8-yl)-benzamide
• CAS NO: 1443788-20-2
• Molecular Weight: 282.729
• Mol File: 1443788-20-2.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: N-(5-chloroquinolin-8-yl)-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-chloroquinolin-8-yl)-benzamide(1443788-20-2)
• EPA Substance Registry System: N-(5-chloroquinolin-8-yl)-benzamide(1443788-20-2)

Safety Data

• Hazardous Substances Data: 1443788-20-2(Hazardous Substances Data)

Upstream product

• 578-66-5 8-amino quinoline 
• 98-88-4 benzoyl chloride 
• 33757-48-1 N-quinolin-8-yl-benzamide 
• 1443788-17-7 N-(5,7-dideuterio-8-quinolinyl)benzamide 
• 580-22-3 2-aminoquinoline 
• 98-59-9 p-toluenesulfonyl chloride 
• 1635-61-6 5-chloro-2-nitroaniline 
• 65-85-0 benzoic acid 
• 5432-09-7 5-chloroquinolin-8-amine 
• 6942-98-9 5-chloro-8-nitroquinoline 

Downstream Products

• 859958-87-5 5-chloro-8-iodoquinoline 

Relevant articles and documents

A Convenient Strategy for Remote C-H Bond Halogenation of 8-Aminoquinolines in the C5 Position

A highly efficient and convenient strategy has been developed for remote C-H bond halogenation of 8-aminoquinolines in good to excellent yields under transition-metal-free conditions. The reaction tolerates a variety of functional groups and can potentially be scaled up.

Cobalt(II)-catalyzed chelation-assisted C-H iodination of aromatic amides with I2

The cobalt-catalyzed chelation-assisted iodination of aromatic amides using molecular I2 as an iodinating reagent is reported. 8-Amino-5-chloroquinoline functions as an efficient directing group. This mild and air stable catalytic system shows a wide functional group tolerance and improved synthetic accessibility.

Transition-metal-free oxidative C5 C-H-halogenation of 8-aminoquinoline amides using sodium halides

A simple and efficient transition-metal-free oxidative halogenation (Cl, Br) of the C5 C-H bond of 8-aminoquinoline amides has been developed. This method employed low-cost and innoxious sodium halides as halogenation reagents and oxone as an oxidant. The

Highly regioselective and stereoselective synthesis of C-Aryl glycosidesvianickel-catalyzedortho-C-H glycosylation of 8-aminoquinoline benzamides

C-Aryl glycosides are of high value as drug candidates. Here a novel and cost-effective nickel catalyzedortho-CAr-H glycosylation reaction with high regioselectivity and excellent α-selectivity is described. This method shows great functional group compatibility with various glycosides, showing its synthetic potential. Mechanistic studies indicate that C-H activation could be the rate-determining step.

Visible-Light-Triggered Decarboxylative Alkylation of 8-Acylaminoquinoline with N -Hydroxyphthalimide Ester

A facile protocol for visible-light-induced decarboxylative radical coupling of NHP esters with 8-aminoquinoline amides is reported, affording a highly efficient approach to synthesize a variety of 2-alkylated or 2,4-dialkylated 8-aminoquinoline derivativ