1443991-50-1

Basic information

• Product Name: 3,4-bis(3-chlorophenyl)-1-ethoxy-7-methylbenz[c-1,2]oxaphosphinine 1-oxide
• Synonyms: 3,4-bis(3-chlorophenyl)-1-ethoxy-7-methylbenz[c-1,2]oxaphosphinine 1-oxide
• CAS NO: 1443991-50-1
• Molecular Weight: 431.255
• Mol File: 1443991-50-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3,4-bis(3-chlorophenyl)-1-ethoxy-7-methylbenz[c-1,2]oxaphosphinine 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-bis(3-chlorophenyl)-1-ethoxy-7-methylbenz[c-1,2]oxaphosphinine 1-oxide(1443991-50-1)
• EPA Substance Registry System: 3,4-bis(3-chlorophenyl)-1-ethoxy-7-methylbenz[c-1,2]oxaphosphinine 1-oxide(1443991-50-1)

Safety Data

• Hazardous Substances Data: 1443991-50-1(Hazardous Substances Data)

Upstream product

• 1754-49-0 diethyl phenylphosphonate 
• 5216-30-8 1,2-bis(3-chlorophenyl)ethyne 
• 4546-19-4 ethyl hydrogen phenylphosphonate 

Relevant articles and documents

NOVEL PHOSPHININE OXIDE DERIVATIVE AND PREPARATION METHOD THEREOF

Provided are a novel phosphinine oxide derivative and a preparation method thereof, and more specifically, the phosphinine oxide derivative includes an oxaphosphinine oxide derivative and an azaphosphinine oxide derivative. The phosphinine oxide derivative according to the present invention may have a pharmacological activity and a physiological activity, and may be used as a basic framework of a natural product and may be used for development of new drug and synthesis of various medical supplies. In addition, according to the preparation method of the phosphinine oxide derivative according to the present invention, various phosphinine oxide derivatives with a high yield may be prepared by a simple synthesis process using an intramolecular annulation between a phosphinic derivative and an alkyne derivative in the presence of a rhodium (Rh) catalyst or a ruthenium (Ru) catalyst and an oxidant.

Ruthenium-catalyzed C-H activation/cyclization for the synthesis of phosphaisocoumarins

An efficient and cost-effective ruthenium-catalyzed oxidative cyclization of phosphonic acid monoesters or phosphinic acids with alkynes has been developed for the synthesis of a wide range of phosphaisocoumarins in good to excellent yields under aerobic conditions. A multitude of arylphosphonic acid monoesters and arylphosphinic acids having electron-donating and -withdrawing groups were oxidatively cyclized. Various diarylacetylenes, dialkylacetylenes, and alkylarylacetylenes effectively underwent the ruthenium-catalyzed oxidative cyclization. A substrate possessing benzoic acid as well as a phenylphosphonic monoester moiety was smoothly cyclized with hex-3-yne to afford a compound having both isocoumarin and phosphaisocoumarin moieties. Alkenylphosphonic monoester afforded phosphorus 2-pyrone through oxidative cyclization with alkyne. Competition experiments between diaryl- and dialkylalkynes and between diarylacetylenes having p-methoxy and p-chloro groups gave results which showed that the present oxidative cyclizations were not affected by the electronic effects of alkynes. Mechanistic studies revealed C-H bond metalation to be the rate-limiting step.