144401-98-9

Basic information

• Product Name: Propanoic acid, 2-[(4-methoxyphenyl)methoxy]-, ethyl ester, (2S)-
• Synonyms: (S)-2-(4-Methoxy-benzyloxy)-propionic acid ethyl ester;(2S) ethyl 2-(p-methoxybenzyloxy)propanoate;ethyl (S)-2-(4-methoxybenzyloxy)propanoate;ethyl (S)-2-(p-methoxybenzyloxy)propanoate;ethyl O-(4-methoxybenzyl)-(S)-lactate;ethyl (S)-2-O-(4'-methoxybenzyl)lactate;(S)-ethyl 2-((4-methoxybenzyl)oxy)propanoate
• CAS NO: 144401-98-9
• Molecular Formula: C13H18O4
• Molecular Weight: 238.284
• Mol File: 144401-98-9.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 2-[(4-methoxyphenyl)methoxy]-, ethyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2-[(4-methoxyphenyl)methoxy]-, ethyl ester, (2S)-(144401-98-9)
• EPA Substance Registry System: Propanoic acid, 2-[(4-methoxyphenyl)methoxy]-, ethyl ester, (2S)-(144401-98-9)

Safety Data

• Hazardous Substances Data: 144401-98-9(Hazardous Substances Data)

Upstream product

• 687-47-8 (S)-Ethyl lactate 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 2746-25-0 p-Methoxybenzyl bromide 
• 105-13-5 4-Methoxybenzyl alcohol 
• 350848-02-1 2-[(4-methoxybenzyl)oxy]-3-nitropyridine 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 606971-95-3 (4S) tert-butyl 4-(p-methoxybenzyloxy)-3-oxopentanoate 
• 606972-00-3 (3S)-1-bromo-3-(p-methoxybenzyloxy)butan-2-one 
• 126361-27-1 (S)-(p-methoxybenzyloxy)propanal 

Relevant articles and documents

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Synthesis of the C6-C14 Fragment of Euphosalicin

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Benzylation of hydroxy groups with tertiary amine as a base

The benzylation of hydroxy groups in the presence of tertiary amines is described. A mixture of an alcohol and a benzyl halide afforded the corresponding benzyl ether in good to excellent yields in the presence of diisopropylethylamine. The importance of solventless conditions was observed. The reaction showed high tolerance to many functional groups including benzoate, even at a reaction temperature of 150 °C. Sodium iodide was found to be an efficient catalyst to accelerate the reaction.