1444154-62-4Relevant articles and documents
Succinct and facile synthesis of innovative thiopyrimidines with antimicrobial and antitubercular investigation
Mistry, Prashant T.,Kamdar, Nimesh R.,Haveliwala, Dhaval D.,Patel, Saurabh K.
, p. 561 - 572 (2013/07/26)
To develop a series of bioactive heterocycles in minimum number of steps, 3-methyl- 4-(substituted phenyl)-1-phenyl-4,8-dihydropyrazolo[4′,3′: 5,6]pyrano[2,3-d]pyrimidine-5,7 (1H,6H)-dithione 2(a-j), 4-(4-substituted phenyl)-5-imino-3-methyl-1,6-diphenyl-4,5,6,8-tetrahydropyrazolo[4′, 3′:5,6]pyrano[2,3-d]pyrimidine-7(1H)-thione 3(a-j), and N-[4-(subs- tituted phenyl)-3-methyl-1-phenyl-7-thioxo-1,4,7,8-hexahydropyrazolo[4′, 3′:5,6]pyrano[2,3-d]pyrimidine-5-yl]thiourea 4(a-j) have been synthesized from amino nitrile functionality 1(a-j). The structures of the compounds were elucidated by IR, 1H NMR, elemental analysis, and some representative 13C NMR and mass spectra. All the title compounds were screened for antimicrobial and antitubercular activities, while some representative compounds were tested for antioxidant activity. Out of synthesized compounds, compounds 1j (4-CH3), 2d (4-F), 4c (4-OH), and 4i (3-Br) exhibited maximum inhibition against Mycobacterium Tuberculosis H37Rv. Compound 3c (4-OH) revealed elevated efficacy against all tested bacterial strain, while compounds 1i (3-Br), 2c (4-OH), and 3h (3-NO2) were found efficacious against Candida albicans as compared to standard drugs. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.
