14446-47-0

Basic information

• Product Name: Thiazolidine, hydrochloride (1:1)
• Synonyms: Thiazolidine, hydrochloride (1:1);Thiazolidine hydrochloride;Thiazolidine hcl;THIAZOLIDINE, HCL (1:1)
• CAS NO: 14446-47-0
• Molecular Formula: C₃H₇NS*ClH
• Molecular Weight: 125.62032
• Mol File: 14446-47-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 180 °C(Solv: water (7732-18-5))
• Appearance: /
• CAS DataBase Reference: Thiazolidine, hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazolidine, hydrochloride (1:1)(14446-47-0)
• EPA Substance Registry System: Thiazolidine, hydrochloride (1:1)(14446-47-0)

Safety Data

• Hazardous Substances Data: 14446-47-0(Hazardous Substances Data)

Usage

General Description

Thiazolidine, hydrochloride (1:1) is a chemical compound with the molecular formula C3H8ClNS. It is a hydrochloride salt form of thiazolidine, a heterocyclic compound containing both a sulfur and nitrogen atom in its five-membered ring structure. Thiazolidine, hydrochloride is commonly used in the synthesis of pharmaceuticals and agrochemicals, as well as in various chemical reactions due to its unique properties. It is also known for its potential anti-inflammatory and anti-cancer activities, making it a subject of interest in medicinal chemistry research. Overall, thiazolidine, hydrochloride (1:1) plays a significant role in the fields of pharmaceuticals, agrochemicals, and medicinal chemistry.

Upstream product

• 50-00-0 formaldehyd 
• 156-57-0 2-mercaptoethylamine hydrochloride 

Downstream Products

• 874509-58-7 3-(4-nitro-benzenesulfonyl)-thiazolidine 
• 667898-99-9 [1-(4-azido-cyclohexyl)-2-oxo-2-thiazolidin-3-yl-ethyl]-carbamic acid tert-butyl ester 
• 133913-49-2 1-phenyl-3-thiazolidin-3-yl-propan-1-one 
• 1024025-54-4 5-phenethyl-2,3,4,7-tetrahydro[1,4]thiazepine-6-carbonitrile 
• 1024025-70-4 5-phenyl-2,3,4,7-tetrahydro[1,4]thiazepine-6-carbonitrile 
• 33744-33-1 β-methylaminoethanethiol hydrochloride 
• 401566-80-1 tert-butyl (2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidine-1-carboxylate 
• 401564-36-1 (2S)-4-oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester 

Relevant articles and documents

Reversible inactivation of bovine plasma amine oxidase by cysteamine and related analogs

Cysteamine (1) was reported many years ago to reversibly inhibit lentil seedling amine oxidase, through the formation of a complex with thioacetaldehyde, the turnover product of 1. Herein, cysteamine (1) and its analogs 2-(methylamino)ethanethiol (3) and 3-aminopropanethiol (6) were found to be reversible inhibitors of bovine plasma amine oxidase (BPAO), but 2-(methylthio)ethylamine (7) was determined to be a weak irreversible inhibitor of BPAO. Based on our results, indicating the necessity of a sulfhydryl-amine for reversible inactivation of BPAO, the failure of inhibited BPAO to recover activity after gel filtration, the first-order kinetics of activity recovery upon dialysis, and 2,4,6-trihydroxyphenylalanine quinine (TPQ) cofactor transformation which indicated from the results of phenylhydrazine titration and substrate protection, we propose a mechanism for the reversible inactivation of BPAO by 1 involving the formation of a cofactor adduct, thiazolidine, between BPAO and 1.

Synthesis of 2,3,4,7-tetrahydro[1,4]thiazepines from thiazolidines and β-enaminonitriles

A wide library of 2,3,4,7-tetrahydro[1,4]thiazepines have been prepared by simple heating of thiazolidine and β-enaminonitrile derivatives in acetonitrile. The procedure, whose yields depend on the nature and position of the substituents, gave good results if the substituents were not very bulky but it is less effective when starting from 2-substituted thiazolidines.