144465-21-4

Basic information

• Product Name: 2-Butenoic acid, 3-[4-(2,4-dichlorophenoxy)phenyl]-, methyl ester
• CAS NO: 144465-21-4
• Molecular Formula: C17H14Cl2O3
• Molecular Weight: 337.202
• Mol File: 144465-21-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 3-[4-(2,4-dichlorophenoxy)phenyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 3-[4-(2,4-dichlorophenoxy)phenyl]-, methyl ester(144465-21-4)
• EPA Substance Registry System: 2-Butenoic acid, 3-[4-(2,4-dichlorophenoxy)phenyl]-, methyl ester(144465-21-4)

Safety Data

• Hazardous Substances Data: 144465-21-4(Hazardous Substances Data)

Upstream product

• 99-93-4 4-Hydroxyacetophenone 
• 1435-48-9 1,3-dichloro-4-fluorobenzene 
• 120-83-2 2,4-dichlorophenol 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 5927-18-4 trimethyl phosphonoacetate 
• 129644-21-9 4-(2,4-Dichlorophenoxy)acetophenone 

Downstream Products

• 144465-12-3 4-[4-(2,4-Dichloro-phenoxy)-phenyl]-5H-furan-2-one 

Relevant articles and documents

3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists

The design, synthesis, and structure-activity relationship (SAR) for a series of β-substituted 3-(4-aryloxyaryl)propanoic acid GPR40 agonists is described. Systematic replacement of the pendant aryloxy group led to identification of potent GPR40 agonists. In order to identify candidates suitable for in vivo validation of the target, serum shifted potency and pharmacokinetic properties were determined for several compounds. Finally, further profiling of compound 7 is presented, including demonstration of enhanced glucose tolerance in an in vivo mouse model.