1445085-55-1 Usage
Description
XPhos Pd G3, a third-generation Buchwald precatalyst, is an air, moisture, and thermally-stable compound that is highly soluble in a wide range of common organic solvents. It offers a long life in solutions and is an excellent reagent for Suzuki cross-coupling reactions, boasting unique features such as lower catalyst loadings, shorter reaction times, efficient formation of the active catalytic species, and accurate control of the ligand: palladium ratio.
Usage:
Used in Pharmaceutical Industry:
XPhos Pd G3 is used as a catalyst for various chemical reactions, including cyanation of heterocyclic halides, coupling of heteroaryl chlorides with polyfluoroaryl zinc reagents, and coupling of 2,6-difluorophenylboronic acid with (hetero)aryl chlorides. These reactions are essential in the synthesis of complex organic molecules, which are often found in pharmaceutical compounds.
Used in Chemical Research:
XPhos Pd G3 is used as a catalyst in chemical research for conducting Suzuki cross-coupling reactions, which are crucial for the formation of carbon-carbon bonds in organic molecules. This application aids in the development of new compounds and materials with potential applications in various industries.
Used in Convenient Dosable Form:
XPhos Pd G3 is available in a convenient dosable form, with 0.025 mmoles per capsule (1EA = 0.025 mmoles), making it easier for researchers and chemists to accurately measure and use the compound in their experiments and reactions.
Reaction
Palladium precatalyst for facile C-N cross-coupling reactions.
Check Digit Verification of cas no
The CAS Registry Mumber 1445085-55-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,5,0,8 and 5 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1445085-55:
(9*1)+(8*4)+(7*4)+(6*5)+(5*0)+(4*8)+(3*5)+(2*5)+(1*5)=161
161 % 10 = 1
So 1445085-55-1 is a valid CAS Registry Number.
1445085-55-1Relevant articles and documents
Design and preparation of new palladium precatalysts for C-C and C-N cross-coupling reactions
Bruno, Nicholas C.,Tudge, Matthew T.,Buchwald, Stephen L.
, p. 916 - 920 (2013/06/05)
A series of easily prepared, phosphine-ligated palladium precatalysts based on the 2-aminobiphenyl scaffold have been prepared. The role of the precatalyst-associated labile halide (or pseudohalide) in the formation and stability of the palladacycle has been examined. It was found that replacing the chloride in the previous version of the precatalyst with a mesylate leads to a new class of precatalysts with improved solution stability and that are readily prepared from a wider range of phosphine ligands. The differences between the previous version of precatalyst and that reported here are explored. In addition, the reactivity of the latter is examined in a range of C-C and C-N bond forming reactions.