14459-29-1 Usage
Description
HEMATOPORPHYRIN, also known as Photodyn or Sensibion, is a dicarboxylic acid that is a derivative of protoporphyrin IX. It is prepared from hemin and has its vinyl groups at positions 7 and 12 replaced by 1-hydroxyethyl groups. HEMATOPORPHYRIN is a porphyrin compound with significant applications in various fields due to its unique properties.
Uses
Used in Photodynamic Therapy:
HEMATOPORPHYRIN is used as a photosensitizer for photodynamic therapy (PDT). It aids in the treatment of various types of cancer by inducing a localized toxic effect on cancer cells when exposed to specific wavelengths of light, leading to cell death.
Used in Antineoplastic Applications:
HEMATOPORPHYRIN serves as an antineoplastic agent, which means it helps in inhibiting or preventing the growth and spread of tumors. Its use in this application is based on its ability to target and destroy cancerous cells when used in conjunction with light therapy.
Used as an Antidepressant:
HEMATOPORPHYRIN has been utilized as an antidepressant since the 1920s. It is believed to exert its effects by modulating the levels of certain neurotransmitters in the brain, thereby alleviating symptoms of depression.
Used as an Antipsychotic:
HEMATOPORPHYRIN has also been employed as an antipsychotic agent, helping in the management of psychiatric disorders such as schizophrenia. Its mechanism of action in this context is not entirely understood but may involve interactions with various neurotransmitter systems in the brain.
Hazard
Toxic. Reported to be preferentially
absorbed by cancerous tissues, making them fluoresce under UV light.
Purification Methods
Purify it by dissolving it in EtOH Hematoporphyrin and adding H2O or Et2O to give deep red crystals. It has also been recrystallised from MeOH. UV has max at 615.5, 565, 534.4 and 499.5nm in 0.1N NaOH, and 597, 619, 634, 653, 683 and 701nm in 2N HCl [Falk Porphyrins and Metalloporphyrins Elsevier, NY, p 175 1964, LCCCNo 63-19821.] It is used in the affinity chromatographic purification of Heme proteins [Olsen Methods Enzymol 123 324 1986]. The O-methyl-dimethyl ester has m 203-206o (from CHCl3/MeOH), and the O,O'-dimethyl-dimethyl ester has m 145o (from CHCl3/MeOH). [Paul Acta Chem Scand 5 389 1951, Beilstein 26 III/IV 3157, and 3158 for the HCl.]
Check Digit Verification of cas no
The CAS Registry Mumber 14459-29-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,4,5 and 9 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 14459-29:
(7*1)+(6*4)+(5*4)+(4*5)+(3*9)+(2*2)+(1*9)=111
111 % 10 = 1
So 14459-29-1 is a valid CAS Registry Number.
InChI:InChI=1/C34H38N4O6/c1-15-21(7-9-31(41)42)27-14-28-22(8-10-32(43)44)16(2)24(36-28)12-29-34(20(6)40)18(4)26(38-29)13-30-33(19(5)39)17(3)25(37-30)11-23(15)35-27/h11-14,19-20,35,38-40H,7-10H2,1-6H3,(H,41,42)(H,43,44)/b23-11-,24-12-,25-11-,26-13-,27-14-,28-14-,29-12-,30-13-
14459-29-1Relevant articles and documents
Interaction of dicarboxylic metalloporphyrins with liposomes. The effect of pH on membrane binding revisited
Kepczynski, Mariusz,Ehrenberg, Benjamin
, p. 486 - 492 (2002)
The acid-base properties of Zn-hematoporphyrin IX (ZnHP) and Zn-mesoporphyrin IX (ZnMP) and the effect of pH on their binding to liposomes have been studied. The ionization constants for the two carboxylate groups of ZnHP were calculated by principal comp
Antibody-therapeutic agent conjugates
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, (2008/06/13)
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