1446470-38-7

Basic information

• Product Name: C₄₅H₄₆N₂O₆
• CAS NO: 1446470-38-7
• Molecular Weight: 710.87
• Mol File: 1446470-38-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₅H₄₆N₂O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₅H₄₆N₂O₆(1446470-38-7)
• EPA Substance Registry System: C₄₅H₄₆N₂O₆(1446470-38-7)

Safety Data

• Hazardous Substances Data: 1446470-38-7(Hazardous Substances Data)

Upstream product

• 125348-34-7 1-0-(Dimethoxytrityl)-3-N-(6-aminocaproyl)-Amino-1,2-Dihydroxypropane 
• 723-62-6 anthracen-9-carboxylic acid 
• 117032-51-6 N-ε-trifluoroacetylaminohexanoic acid N-hydroxysuccinimide ester 

Downstream Products

• 1446470-39-8 C₅₄H₆₃N₄O₇P 

Relevant articles and documents

New synthetic substrates of mammalian nucleotide excision repair system

DNA probes for the studies of damaged strand excision during the nucleotide excision repair (NER) have been designed using the novel non-nucleosidic phosphoramidite reagents that contain N-[6-(9-antracenylcarbamoyl)hexanoyl]-3- amino-1,2-propandiol (nAnt) and N-[6-(5(6)-fluoresceinylcarbamoyl)hexanoyl]-3- amino-1,2-propandiol (nFlu) moieties. New lesion-imitating adducts being inserted into DNA show good substrate properties in NER process. Modified extended linear nFlu- and nAntr-DNA are suitable for estimation of specific excision activity catalysed with mammalian whole-cell extracts. The following substrate activity range was revealed for the model 137-bp linear double-stranded DNA: nAnt-DNA ≈ nFlu-DNA > Chol-DNA (Chol-DNA - legitimate NER substrate that contains non-nucleoside fragment bearing cholesterol residue). In vitro assay shows that modified DNA can be a useful tool to study NER activity in whole-cell extracts. The developed approach should be of general use for the incorporation of NER-sensitive distortions into model DNAs. The new synthetic extended linear DNA containing bulky non-nucleoside modifications will be useful for NER mechanism study and for applications.