1446484-42-9

Basic information

• Product Name: (S)-cyanomethyl 2-((tert-butoxycarbonyl)amino)-4-(phenyldisulfanyl)butanoate
• CAS NO: 1446484-42-9
• Molecular Weight: 382.505
• Mol File: 1446484-42-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-cyanomethyl 2-((tert-butoxycarbonyl)amino)-4-(phenyldisulfanyl)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-cyanomethyl 2-((tert-butoxycarbonyl)amino)-4-(phenyldisulfanyl)butanoate(1446484-42-9)
• EPA Substance Registry System: (S)-cyanomethyl 2-((tert-butoxycarbonyl)amino)-4-(phenyldisulfanyl)butanoate(1446484-42-9)

Safety Data

• Hazardous Substances Data: 1446484-42-9(Hazardous Substances Data)

Upstream product

• 130981-51-0 (2S,2'S)-4,4'-disulfanediylbis(2-(tert-butoxycarbonyl)amino)butanoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1446484-50-9 (S)-(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl 2-amino-4-(phenyldisulfanyl)butanoate 
• 1446484-46-3 (S)-(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-3-yl 2-((tert-butoxycarbonyl)amino)-4-(phenyldisulfanyl)butanoate 

Relevant articles and documents

Expressed protein ligation at methionine: N-terminal attachment of homocysteine, ligation, and masking

A useful handle: One major limitation of protein semi-synthesis is the need for Cys at the ligation site in native chemical ligation reactions. It is shown that a transferase enzyme can deliver homocysteine to the N-terminus of an expressed protein (see scheme). Homocysteine can be used in a ligation reaction and then converted to Met. This allows one to use the MetArg or MetLys motif as a point of disconnection in semi-synthesis. Copyright