1446499-23-5Relevant articles and documents
Synthesis and evaluation of hetero- and homodimers of ribosome-targeting antibiotics: Antimicrobial activity, in vitro inhibition of translation, and drug resistance
Berkov-Zrihen, Yifat,Green, Keith D.,Labby, Kristin J.,Feldman, Mark,Garneau-Tsodikova, Sylvie,Fridman, Micha
, p. 5613 - 5625 (2013/07/26)
In this study, we describe the synthesis of a full set of homo- and heterodimers of three intact structures of different ribosome-targeting antibiotics: tobramycin, clindamycin, and chloramphenicol. Several aspects of the biological activity of the dimeri