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1446512-33-9

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1446512-33-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1446512-33-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,6,5,1 and 2 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1446512-33:
(9*1)+(8*4)+(7*4)+(6*6)+(5*5)+(4*1)+(3*2)+(2*3)+(1*3)=149
149 % 10 = 9
So 1446512-33-9 is a valid CAS Registry Number.

1446512-33-9Downstream Products

1446512-33-9Relevant articles and documents

Structure, synthesis, and biological activity of a C-20 bisacetylenic alcohol from a marine sponge Callyspongia sp.

Shirouzu, Takayuki,Watari, Kousuke,Ono, Mayumi,Koizumi, Keiichi,Saiki, Ikuo,Tanaka, Chiaki,Van Soest, Rob W. M.,Miyamoto, Tomofumi

, p. 1337 - 1342 (2013/08/23)

An optically inactive C-20 bisacetylenic alcohol, (4E,16E)-icosa-4,16- diene-1,19-diyne-3,18-diol, was isolated from a marine sponge Callyspongia sp. as a result of screening of antilymphangiogenic agents from marine invertebrates. An optical resolution using chiral-phase HPLC gave each enantiomer, (-)-1 and (+)-2. Because the natural and synthetic enantiomers 1 and 2 showed different biological properties, we investigated the structure-activity relationships of bisacetylenic alcohols using 11 synthetic derivatives, and it is clarified that the essential structural unit for antiproliferative activity is the "1-yn-3-ol" on both termini and that there is a minimum chain length that connects the "1-yn-3-ol" moieties.

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