144689-94-1Relevant articles and documents
An improved synthesis of 2-n-(propyl)-1H-imidazole-4,5-dicarboxylic acid diethyl ester
Wen, Xinmin,Yu, Xinhong,Tang, Jan
, p. 410 - 412 (2006)
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Synthesis method of olmesartan intermediate
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Paragraph 0033; 0036-0039, (2020/06/17)
The invention relates to the field of drug intermediate synthesis, in particular to a synthesis method of an olmesartan intermediate, which is characterized in that tartaric acid is used as a raw material, and the olmesartan intermediate is prepared by cyclization reaction, esterification reaction and methylation reaction. According to the synthesis method of the olmesartan intermediate, the totalyield can reach 60% or above, the yield is high, and economic benefits are high; the synthesis route is simple, basic raw materials are cheaper, side reactions are few, and purification is easy; andthe whole steps are easy to control, the method is more suitable for industrial application from raw materials to production, selection of ingredients and determination of the addition amount, and theproduction cost is low.
2-aminoalkylimidazole -4, 5-dicarboxilic manufacturing method
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Paragraph 0097, (2016/12/12)
PROBLEM TO BE SOLVED: To provide a method for producing inexpensively with a high yield, 2-alkylimidazole-4,5-dicarboxylic acid which is useful as a medicinal intermediate. SOLUTION: In this method for producing 2-alkylimidazole-4,5-dicarboxylic acid, tartaric acid is dissolved into nitric acid and then reacted with concentrated sulfuric acid, and a nitrate of tartaric acid acquired by the reaction is added into a solvent containing at least one kind of organic solvent selected from among N-methyl-2-pyrrolidone, dimethylformamide, dimethylacetamide, methylcyclohexane and toluene. Thereafter, a mixed liquid of aldehyde and ammonia is added to the reaction liquid, to thereby produce 2-alkylimidazole-4,5-dicarboxylic acid. COPYRIGHT: (C)2012,JPOandINPIT