1447172-64-6

Basic information

• Product Name: N-methyl-N-(2-(phenylsulfonyl)phenyl)formamide
• Synonyms: N-methyl-N-(2-(phenylsulfonyl)phenyl)formamide
• CAS NO: 1447172-64-6
• Molecular Weight: 275.328
• Mol File: 1447172-64-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-methyl-N-(2-(phenylsulfonyl)phenyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-(2-(phenylsulfonyl)phenyl)formamide(1447172-64-6)
• EPA Substance Registry System: N-methyl-N-(2-(phenylsulfonyl)phenyl)formamide(1447172-64-6)

Safety Data

• Hazardous Substances Data: 1447172-64-6(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 53973-76-5 N-methyl-2-(phenylsulfonyl)aniline 

Downstream Products

• 107517-59-9 N,N-dimethyl-2-(phenylsulfonyl)aniline 

Relevant articles and documents

Synthesis of substituted diphenyl sulfones and their structure-activity relationship with the antagonism of 5-HT6 receptors

Substituted diphenyl sulfones (10a-n) were synthesised, and the structures were confirmed by NMR, LC-MS and X-ray crystallography. Their antagonistic activities towards 5-HT6 receptor were assessed in a cell-based functional assay. Diphenyl sulfone 10a, in spite of being the smallest and simplest known sulfonyl-containing 5-HT6R antagonist, showed a strong potency (Ki = 1.6 μM). Its derivative with a methylamine substituent, 10g (N-methyl-2-(phenylsulfonyl)aniline), was ～66-times as active as diphenyl sulfone (Ki = 24.3 nM). Addition of a piperazinyl moiety in the para-position relative to the sulfonyl group in compound 10m (N-methyl-2-(phenylsulfonyl)-5-piperazin-1-ylaniline) led to a further 150-fold increase in potency (Ki = 0.16 nM) to block the serotonin-induced response of HEK-293 cells that were stably transfected with the human recombinant 5-HT6 receptor.