1447666-75-2Relevant articles and documents
Gold-Catalyzed Regiospecific Hydration of N-Tosyl Propargylic Amines
Ying, Jun,Wang, Hai,Qi, Xinxin,Peng, Jin-Bao,Wu, Xiao-Feng
, p. 2837 - 2841 (2018/09/12)
A gold-catalyzed regiospecific hydration of N-tosyl propargylic amines has been developed. In the presence of a catalytic amount of the gold catalyst NaAuCl4·2H2O, both alkyl and aryl-substituted N-tosyl propargylic amines were smoothly converted into the corresponding β-amino ketones with excellent regioselectivities and high yields (up to 85%). Further transformations of the obtained β-amino ketones to valuable 1,3-amino alcohols were demonstrated as well.