1447727-78-7

Basic information

• Product Name: N-(4-methoxybenzyl)-5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-amine
• CAS NO: 1447727-78-7
• Molecular Weight: 332.34
• Mol File: 1447727-78-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-methoxybenzyl)-5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxybenzyl)-5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-amine(1447727-78-7)
• EPA Substance Registry System: N-(4-methoxybenzyl)-5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-amine(1447727-78-7)

Safety Data

• Hazardous Substances Data: 1447727-78-7(Hazardous Substances Data)

Upstream product

• 2393-23-9 4-methoxy-benzylamine 
• 4015-11-6 2-chloro-5-(5-nitrofuran-2-yl)-1,3,4-thiadiazole 
• 712-68-5 2-amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole 

Relevant articles and documents

New 5-(nitroheteroaryl)-1,3,4-thiadiazols containing acyclic amines at C-2: Synthesis and SAR study for their antileishmanial activity

A novel series of 5-(5-nitrofuran-2-yl)-and 5-(5-nitrothiophen-2-yl)-1,3,4- thiadiazole-2-amines bearing acyclic amine at C-2 position of thiadiazole ring were synthesized and evaluated in vitro against promastigote and amastigote forms of Leishmania major. The structure-activity of series was investigated by studying 40 compounds. The most active derivatives were hydroxypropylamino-and methoxypropylamino-analogs of 5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazole (compounds 29 and 32, respectively) with highest selectivity index (SI >12).