144774-99-2

Basic information

• Product Name: 2-Phenyl-1-thiazol-2-yl-ethanone
• Synonyms: 2-Phenyl-1-thiazol-2-yl-ethanone
• CAS NO: 144774-99-2
• Molecular Formula: C₁₁H₉NOS
• Molecular Weight: 203
• Mol File: 144774-99-2.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Phenyl-1-thiazol-2-yl-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenyl-1-thiazol-2-yl-ethanone(144774-99-2)
• EPA Substance Registry System: 2-Phenyl-1-thiazol-2-yl-ethanone(144774-99-2)

Safety Data

• Hazardous Substances Data: 144774-99-2(Hazardous Substances Data)

Upstream product

• 3034-53-5 2-bromo-1,3-thiazole 
• 95092-10-7 N-methoxy-N-methyl-2-phenylacetamide 
• 103-80-0 phenylacetyl chloride 
• 103-82-2 phenylacetic acid 
• 100-39-0 benzyl bromide 
• 79265-30-8 2-(trimethylsilyl)thiazole 
• 288-47-1 1,3-thiazole 

Downstream Products

• 144775-00-8 benzyl 2-thiazolyl ketone O-methyloxime 
• 144775-02-0 benzyl 2-thiazolyl ketone O-benzyloxime 
• 144775-05-3 2-phenyl-1-(thiazol-2-yl)ethanol 
• 144831-03-8 (1R)-2-phenyl-1-(1,3-thiazol-2-yl)ethan-1-ol 
• 144831-04-9 (S)-2-phenyl-1-(thiazol-2-yl)ethanol 
• 130199-65-4 (1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethan-1-amine 
• 120205-51-8 tert-butyl N-[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]carbamate 
• 144775-06-4 2-[(1S)-1-azido-2-phenylethyl]-1,3-thiazole 
• 120205-54-1 tert-butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidine-1-carboxylate 

Relevant articles and documents

CONJUGATE OF MONOMETHYL AURISTATIN F AND TRASTUZUMAB AND ITS USE FOR THE TREATMENT OF CANCER

The present invention relates to an antibody-drug-conjugate or pharmaceutical composition comprising the same. From one aspect, the invention relates to an antibody-drug-conjugate (ADC) comprising an antibody consisting of the Trastuzumab or a biosimilar thereof, said antibody being conjugated to at least one drug consisting of a monomethyl auristatin F derivative. The invention also comprises method of treatment of cancer comprising administering to the subject an effective amount of said antibody-drug-conjugate or composition comprising the same.

Octahedral iridium complex catalyzed α-chlorination of 2-acyl imidazoles with tosyl chloride

An efficient and catalytic α-chlorination of 2-acyl imidazoles with readily available tosyl chloride catalyzed by an octahedral iridium complex under mild condition was reported. A range of 2-acyl imidazoles were converted to their corresponding α-chlorin

ANTIBODY-DRUG-CONJUGATE AND ITS USE FOR THE TREATMENT OF CANCER

The present invention relates to an antibody-drug-conjugate. From one aspect, the invention relates to an antibody-drug-conjugate comprising an antibody capable of binding to a Target, said antibody being conjugated to at least one drug selected from derivatives of dolastatin 10 and auristatins. The invention also comprises method of treatment and the use of said antibody-drug-conjugate for the treatment of cancer.