14478-13-8

Basic information

• Product Name: 1-Cycloocten-1-ol 1-Acetate
• Synonyms: 1-Cycloocten-1-ol 1-Acetate
• CAS NO: 14478-13-8
• Molecular Formula: C₁₀H₁₆O₂
• Molecular Weight: 168.23284
• Product Categories: Aliphatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 14478-13-8.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: DCM, Ethyl Acetate
• CAS DataBase Reference: 1-Cycloocten-1-ol 1-Acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cycloocten-1-ol 1-Acetate(14478-13-8)
• EPA Substance Registry System: 1-Cycloocten-1-ol 1-Acetate(14478-13-8)

Safety Data

• Hazardous Substances Data: 14478-13-8(Hazardous Substances Data)

Usage

Description

1-Cycloocten-1-ol 1-Acetate is a chemical compound derived from cyclooctanone, which is an aliphatic cycle. It has been found to exhibit inhibitory activity towards aldosterone synthase, making it a potential therapeutic target for the treatment of cardiovascular diseases related to abnormally high aldosterone levels.

Uses

Used in Pharmaceutical Industry:
1-Cycloocten-1-ol 1-Acetate is used as a therapeutic agent for the treatment of cardiovascular diseases. Its inhibitory activity towards aldosterone synthase makes it a promising candidate for targeting conditions related to abnormally high aldosterone levels, which can contribute to the development of various cardiovascular diseases.
Used in Drug Development:
1-Cycloocten-1-ol 1-Acetate is used as a lead compound in the development of new drugs aimed at treating cardiovascular diseases. Its ability to inhibit aldosterone synthase suggests that it could be a valuable starting point for the design and synthesis of more potent and selective inhibitors, potentially leading to the creation of novel therapeutics for the treatment of related conditions.

Upstream product

• 108-22-5 Isopropenyl acetate 
• 502-49-8 cycloactanone 
• 108-24-7 acetic anhydride 
• 931-88-4 cis-Cyclooctene 
• 64-19-7 acetic acid 
• 108-21-4 Isopropyl acetate 

Downstream Products

• 502-49-8 cycloactanone 
• 23202-10-0 (Z)-cyclooct-2-enone 
• 1755-14-2 α-fluorocycloctanone 

Relevant articles and documents

A New Method of Synthesizing 7-(2-Hydroxy-5-oxo-1-cyclopentenyl)heptanoic Acid and Related Compounds

A useful prostanoid synthon, 7-(2-hydroxy-5-oxo-1-cyclopentenyl)heptanoic acid (3), was prepared from commercially available cyclooctanone in two steps.Nine other related cyclopentanoids which are also valuable synthons for prostaglandins were obtained from 3 in reasonable yields via several steps.The procedure is capable of generating these synthons on a laboratory scale.

A Short Synthesis of 15-Dehydroprostaglandin B1 Methyl Ester

A new synthetic method for 15-dehydroprostaglandin B1 methyl ester (15-dehydroPGB1 methyl ester) in four steps from commercially available starting materials is described.

Reductive Coupling between C-N and C-O Electrophiles

The cross-electrophile reaction is a promising strategy for C-C bond formation. Recent studies have focused mainly on reactions with organic halides. Here we report a coupling reaction between C-N and C-O electrophiles that demonstrates the possibility of constructing a C-C bond via C-N and C-O cleavage. Several reactions between benzyl/aryl ammonium salts and vinyl/aryl C-O electrophiles have been studied. Preliminary mechanistic studies revealed that the benzyl ammoniums were activated through a radical mechanism.

Practical and User-Friendly Procedure for Michael Reactions of α-Nitroketones in Water

A variety of α,β-unsaturated carbonyl derivatives gave selective Michael additions with several α-nitrocycloalkanones in water, at room temperature without any added catalyst, or in very dilute, aqueous solutions of potassium carbonate. Both preparative methods constitute new, environmentally benign and more efficient alternatives to previous procedures.