1448190-05-3

Basic information

• Product Name: tert-butyl 4-(2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)benzylcarbamate
• Synonyms: tert-butyl 4-(2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)benzylcarbamate
• CAS NO: 1448190-05-3
• Molecular Weight: 340.379
• Mol File: 1448190-05-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)benzylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)benzylcarbamate(1448190-05-3)
• EPA Substance Registry System: tert-butyl 4-(2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)benzylcarbamate(1448190-05-3)

Safety Data

• Hazardous Substances Data: 1448190-05-3(Hazardous Substances Data)

Upstream product

• 14733-73-4 5-bromo-1,3-benzoxazol-2(3H)-one 
• 489446-42-6 4-((tert-butoxycarbonylamino)methyl)phenylboronic acid 

Downstream Products

• 1448187-28-7 (2S,4R)-4-hydroxy-1-(2-(3-methylisoxazol-5-yl)acetyl)-N-(4-(2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)benzyl)pyrrolidine-2-carboxamide 
• 1448189-56-7 5-(4-(aminomethyl)phenyl)benzo[d]oxazol-2(3H)-one hydrochloride 

Relevant articles and documents

Compounds & Methods for the Enhanced Degradation of Targeted Proteins & Other Polypeptides by an E3 Ubiquitin Ligase

The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins that are degraded and/or otherwise inhibited by bifunctional compounds of the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand that binds to the ubiquitin ligase and on the other end a moiety that binds a target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds of the present invention, consistent with the degradation/inhibition of targeted polypeptides.