1448458-23-8

Basic information

• Product Name: C₂₀H₁₅ClN₄O₂S
• CAS NO: 1448458-23-8
• Molecular Weight: 410.884
• Mol File: 1448458-23-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₅ClN₄O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₅ClN₄O₂S(1448458-23-8)
• EPA Substance Registry System: C₂₀H₁₅ClN₄O₂S(1448458-23-8)

Safety Data

• Hazardous Substances Data: 1448458-23-8(Hazardous Substances Data)

Upstream product

• 86-98-6 4,7-dichloroquinoline 
• 144-83-2 sulphapyridine 

Relevant articles and documents

Discovering some novel 7-chloroquinolines carrying a biologically active benzenesulfonamide moiety as a new class of anticancer agents

Based on the reported anticancer activity of quinolines, a new series of 7-chloroquinoline derivatives bearing the biologically active benzenesulfonamide moiety 2-17 and 19-25 were synthesized starting with 4,7-dichloroquinolne 1. Compound 17 was the most active compound with IC50 value 64.41, 75.05 and 30.71μm compared with Doxorubicin as reference drug with IC50 values 82.53, 88.32 and 73.72 μm on breast cancer cells, skin cancer cells and neuroblastoma, respectively. All the synthesized compounds were evaluated for their in vitro anticancer activity on breast cancer cells, skin cancer cells and neuroblastoma cells. Most of the synthesized compounds showed moderate activity. In order to suggest the mechanism of action for their cytotoxic activity, molecular docking for all synthesized compounds was done on the active site of phosphoinositide kinase (PI3K) and good results were obtained.