144852-07-3Relevant articles and documents
Structure-activity relationship of wedelolactone analogues: Structural requirements for inhibition of Na+,K+-ATPase and binding to the central benzodiazepine receptor
Pocas, Elisa S.C.,Lopes, Daniele V.S.,da Silva, Alcides J.M.,Pimenta, Paulo H.C.,Leitao, Fernanda B.,Netto, Chaquip D.,Buarque, Camilla D.,Brito, Flavia V.,Costa, Paulo R.R.,Noel, Francois
, p. 7962 - 7966 (2007/10/03)
Coumestans 2a-i, bearing different patterns of substitution in A- and D-rings, were synthesized and evaluated as inhibitors of kidney Na+,K+-ATPase and ligands for the central benzodiazepine (BZP) receptor. The presence of a hydroxyl group in position 2 favours the effect on Na+,K+-ATPase but decreases the affinity for the BZP receptor, allowing the design of more selective molecules than the natural wedelolactone. On the other hand, the presence of a catechol in ring D is important for the effect on both molecular targets.
Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation
Da Silva, Alcides J.M.,Melo, Paulo A.,Silva, Noelson M.V.,Brito, Flavia V.,Buarque, Camilla D.,De Souza, Daniele V.,Rodrigues, Veronica P.,Pocas, Elisa S.C.,Noel, Francois,Albuquerque, Edson X.,Costa, Paulo R.R.
, p. 283 - 286 (2007/10/03)
Five coumestans with different patterns of oxygenation in rings A and D were synthesized from resorcinol and aromatic aldehydes, and screened for their antimyotoxic activity. The most potent compound (2b, IC50 = 1 μM) was selected for study of
