14486-52-3

Basic information

• Product Name: 1-Methyl-2-(Methylthio)iMidazole
• Synonyms: 1-Methyl-2-(Methylthio)iMidazole;1-Methyl-2-(methylsulphanyl)-1H-imidazole;1-METHYL-2-(METHYLTHIO)IMIDAZOLE(2MMI);2-Methylthio-3-methylimidazole;1H-Imidazole, 1-methyl-2-(methylthio)-
• CAS NO: 14486-52-3
• Molecular Formula: C₅H₈N₂S
• Molecular Weight: 128.19542
• Product Categories: Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 14486-52-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 166 °C(Press: 30 Torr)
• Appearance: /
• Density: 1.14±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 5.88±0.25(Predicted)
• CAS DataBase Reference: 1-Methyl-2-(Methylthio)iMidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-2-(Methylthio)iMidazole(14486-52-3)
• EPA Substance Registry System: 1-Methyl-2-(Methylthio)iMidazole(14486-52-3)

Safety Data

• Hazardous Substances Data: 14486-52-3(Hazardous Substances Data)

Usage

Description

1-Methyl-2-(Methylthio)imidazole, also known as Methimazole USP Related Compound C, is an organic compound that is identified as an impurity in Methimazole (M260300). Methimazole is a thiourea antithyroid agent utilized in the treatment of hyperthyroidism. The compound possesses a unique chemical structure with a methyl group and a methylthio group attached to the imidazole ring, which may contribute to its presence as an impurity in the pharmaceutical compound.

Uses

Used in Pharmaceutical Industry:
1-Methyl-2-(Methylthio)imidazole is used as an impurity in the production of Methimazole (M260300), a thiourea antithyroid agent. Its presence is significant as it is derived from the synthesis process of the primary compound, Methimazole. Methimazole functions by preventing iodine organification, which in turn inhibits the synthesis of thyroxine, a hormone responsible for regulating the body's metabolism. The management of this impurity is crucial for ensuring the safety, efficacy, and quality of the final pharmaceutical product.

Upstream product

• 616-47-7 1-methyl-1H-imidazole 
• 624-92-0 Dimethyldisulphide 
• 60-56-0 1-methyl-1,3-dihydro-imidazole-2-thione 
• 77-78-1 dimethyl sulfate 
• 18805-25-9 methyl carbonimidodithioic acid dimethyl ester 
• 645-36-3 2,2-diethoxy-ethanamine 
• 74-88-4 methyl iodide 
• 186581-53-3 diazomethane 
• 60-56-0 2-Mercapto-1-methylimidazole 
• 67-56-1 methanol 
• 872-35-5 1,3-dihydro-imidazole-2-thione 

Downstream Products

• 71691-71-9 1-methyl-2-(methylsulfonyl)-1H-imidazole 
• 142132-87-4 2-methanesulfinyl-1-methyl-imidazole 
• 1615-41-4 1-methyl-2-(methylsulfanyl)-5-nitro-1H-imidazole 
• 1615-53-8 1-methyl-2-methylsulphonyl-5-nitro-imidazole 
• 1158911-00-2 N-(4-nitrobenzenesulfonyl) methyl[2-(n-methylimidazolyl)]sulfilimine 
• 1227186-61-9 C₁₁H₁₂ClN₂PS 
• 1227186-20-0 C₁₇H₁₇N₂PS 

Relevant articles and documents

S-methylation of N-containing heterocyclic thiols with conjugated acids of methoxy groups

2-Mercaptopyridine-3-carboxylic acid reacts with methanol under acidic conditions to afford the corresponding S-methylated methyl ester, methyl 2-methylthiopyridine-2-carboxylate. Such S-methylation occurred for various N-containing heterocyclic thiols wi

Applications of 15N NMR to a Study of Tautomerism in Some Monocyclic Azoles

15N NMR shielding measurements reveal that thiolo-imidazole and -tetrazole exist almost entirely as the thione form.Quantitative estimates of the position of tautomerism in 1,2,3-triazole and tetrazole are obtained.The reported assignments are supported by means of INDO/S-SOS shielding calculations.

1-dethia-2-thia-cephalosporanic acids

Novel 1-dethia-2-thia-cephalosporanic acid derivatives of the formula STR1 wherein R is selected from the group consisting of STR2 Ra is an organic radical, Ri and Rj are individually selected from the group consisting of hydrogen, aliphatic, aromatic and heterocycle or taken together with the nitrogen atom to which they are attached form an optionally substituted cycle or Rb NH--, Rb is optionally substituted carbocyclic or heterocyclic aryl, R1 and --COM are as defined in the specification, R4 is hydrogen or methoxy, n2 is 0, 1 or 2 and their non-toxic, pharmaceutically acceptable acid addition salts in racemic or optically active form having antibiotic activity and their preparation and novel intermediates.