144878-40-0

Basic information

• Product Name: (2E)-3-(4-ethoxy-3-methoxyphenyl)acrylic acid
• Synonyms: Albb-006670;(2E)-3-(4-ethoxy-3-methoxyphenyl)acrylic acid(SALTDATA: FREE);(E)-3-(4-ethoxy-3-methoxy-phenyl)prop-2-enoic acid;(E)-3-(4-ethoxy-3-methoxyphenyl)prop-2-enoic acid;3-(4-ethoxy-3-methoxy-phenyl)acrylic acid;SBB015395;ST5135982;(2E)-3-(4-ethoxy-3-methoxyphenyl)prop-2-enoic acid
• CAS NO: 144878-40-0
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.24
• Mol File: 144878-40-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 378.5°C at 760 mmHg
• Flash Point: 145.1°C
• Appearance: /
• Density: 1.172g/cm³
• Vapor Pressure: 2.1E-06mmHg at 25°C
• Refractive Index: 1.564
• PKA: 4.54±0.10(Predicted)
• CAS DataBase Reference: (2E)-3-(4-ethoxy-3-methoxyphenyl)acrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-(4-ethoxy-3-methoxyphenyl)acrylic acid(144878-40-0)
• EPA Substance Registry System: (2E)-3-(4-ethoxy-3-methoxyphenyl)acrylic acid(144878-40-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 144878-40-0(Hazardous Substances Data)

Usage

General Description

"(2E)-3-(4-ethoxy-3-methoxyphenyl)acrylic acid" is a chemical compound with the molecular formula C12H14O4. It is composed of a 3-(4-ethoxy-3-methoxyphenyl)acrylic acid group, which consists of a benzene ring substituted with an ethoxy and methoxy group, and an acrylic acid moiety. (2E)-3-(4-ethoxy-3-methoxyphenyl)acrylic acid has potential applications in the fields of organic synthesis, pharmaceuticals, and materials science. It may also exhibit biological activities, such as antioxidant and anti-inflammatory properties. Further research is needed to explore the full range of its potential uses and effects.

InChI:InChI=1/C12H14O4/c1-3-16-10-6-4-9(5-7-12(13)14)8-11(10)15-2/h4-8H,3H2,1-2H3,(H,13,14)/b7-5+

Upstream product

• 127057-19-6 (2E)-3-(4-ethoxy-3-methoxyphenyl)acrylaldehyde 
• 141-82-2 malonic acid 
• 120-25-2 4-ethoxy-3-methoxybenzaldehyde 
• 121-33-5 vanillin 
• 875855-05-3 1-(4-ethoxy-3-methoxy-phenyl)-prop-2-yn-1-ol 
• 1135-24-6 (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid 
• 75332-48-8 ethyl 3-(4'-ethoxy-3'-methoxyphenyl)propanoate 

Downstream Products

• 75332-48-8 ethyl 3-(4'-ethoxy-3'-methoxyphenyl)propanoate 
• 144878-46-6 acetic acid 
• 1630949-78-8 C₂₄H₂₁NO₆ 

Relevant articles and documents

Synthesis, antiviral activity, and molecular docking study of trans-ferulic acid derivatives containing acylhydrazone moiety

In this study, we report the synthesis and antiviral activity of trans-ferulic acid derivatives containing acylhydrazone moiety. Biological tests demonstrated that most target compounds showed potent antiviral activity against tobacco mosaic virus (TMV). Compound D4 showed remarkable inactivating activity with EC50 value of 36.59 μg/mL, which was obviously superior to ribavirin (126.05 μg/mL). Molecular docking results revealed that compound D4 exhibited the optimal combining capacity with five hydrogen bonds to different amino-acid residues of TMV coat protein (TMV-CP). Docking results were consistent with the inactivating activity of target compounds against TMV.

Synthesis and mesomorphic behavior of calamitic liquid crystals with a biphenyl moiety

A new mesogenic homologous series having a biphenyl moiety has been synthesized by condensing 4-hydroxy-4′-nitrobiphenyl- and methoxy-substituted 4-n-alkoxy cinnamoyl chlorides, and their liquid crystalline properties have been studied. All the members of the series are enantiotropic liquid crystals. The methyl to n-pentyl derivatives exhibit both Smectic A (SmA) and Nematic (N) phases; the higher members, starting with the n-hexyl derivative show only a SmA phase. The plot of transition temperatures versus number of carbon atoms in the alkoxy chain exhibits zig-zag pattern for Sm-N and NIsotropic (Iso) transition temperature curves. The average thermal stability is compared with other related homologous series. The introduction of polar nitro group increases significant intermolecular force of attraction which stabilizes the molecular orientation. This results into the increase in the thermal stability of the system.