144882-51-9

Basic information

• Product Name: 1-(iminophenylmethyl)-3-methylpyrrolo<1,2-a>azepane
• CAS NO: 144882-51-9
• Molecular Weight: 252.359
• Mol File: 144882-51-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(iminophenylmethyl)-3-methylpyrrolo<1,2-a>azepane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(iminophenylmethyl)-3-methylpyrrolo<1,2-a>azepane(144882-51-9)
• EPA Substance Registry System: 1-(iminophenylmethyl)-3-methylpyrrolo<1,2-a>azepane(144882-51-9)

Safety Data

• Hazardous Substances Data: 144882-51-9(Hazardous Substances Data)

Upstream product

• 3338-03-2 2-methyl-4,5,6,7-tetrahydro-3H-azepine 
• 100-47-0 benzonitrile 
• 106-96-7 propargyl bromide 

Downstream Products

• 144882-53-1 C-(3-Methyl-6,7,8,9-tetrahydro-5H-pyrrolo[1,2-a]azepin-1-yl)-C-phenyl-methylamine 

Relevant articles and documents

An efficient approach to pyrroles and N-bridgehead pyrroles by propargylation/cycloamination of 4-amino-1-azabutadiene derivatives

The thermal cycloamination of several propargyl-substituted 4-amino-1-azabutadienes 2 leading to 3-functionalized pyrroles 4-6 is described. Derivatives of pyrrolizidines 9 and indolizidines and azaazulenes 11-13 are synthesized directly from cyclic imines 7 and 10, respectively, in a multistep process that involves metalation with LDA, addition of a nitrile, carbanion trapping with propargyl bromide, and cycloamination. In all cases the more substituted imine nitrogen is involved in the cyclization reaction; such an experimental finding is supported by theoretical calculations.