1448848-29-0

Basic information

• Product Name: (R,2E,4E)-6-((tert-butyldimethylsilyl)oxy)-7-(3,4-dimethoxyphenyl)hepta-2,4-dienoic acid
• Synonyms: (R,2E,4E)-6-((tert-butyldimethylsilyl)oxy)-7-(3,4-dimethoxyphenyl)hepta-2,4-dienoic acid
• CAS NO: 1448848-29-0
• Molecular Weight: 392.568
• Mol File: 1448848-29-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R,2E,4E)-6-((tert-butyldimethylsilyl)oxy)-7-(3,4-dimethoxyphenyl)hepta-2,4-dienoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R,2E,4E)-6-((tert-butyldimethylsilyl)oxy)-7-(3,4-dimethoxyphenyl)hepta-2,4-dienoic acid(1448848-29-0)
• EPA Substance Registry System: (R,2E,4E)-6-((tert-butyldimethylsilyl)oxy)-7-(3,4-dimethoxyphenyl)hepta-2,4-dienoic acid(1448848-29-0)

Safety Data

• Hazardous Substances Data: 1448848-29-0(Hazardous Substances Data)

Upstream product

• 5703-21-9 3,4-dimethoxyphenylacetaldehyde 
• 61871-67-8 3-(3,4-Dimethoxyphenyl)propanal 
• 3929-47-3 3-(3,4-dimethoxyphenyl)-1-propanol 
• 1448848-28-9 (R,2E,4E)-ethyl 6-((tert-butyldimethylsilyl)oxy)-7-(3,4-dimethoxyphenyl)hepta-2,4-dienoate 
• 1448848-24-5 (R,E)-ethyl5-(3,4-dimethoxyphenyl)-4-hydroxypent-2-enoate 
• 1448848-32-5 C₁₉H₃₀O₄Si 
• 1448848-26-7 (R,E)-4-((tert-butyldimethylsilyl)oxy)-5-(3,4-dimethoxyphenyl)pent-2-en-1-ol 
• 1448848-25-6 (R,E)-ethyl-4-((tert-butyldimethylsilyl)oxy)-5-(3,4-dimethoxyphenyl)pent-2-enoate 

Downstream Products

• 1448848-27-8 (R,2E,4E)-6-((tert-Butyldimethylsilyl)oxy)-7-(3,4-dimethoxyphenyl)-N-ethylhepta-2,4-dienamide 

Relevant articles and documents

Synthesis and biological evaluation of (-)-kunstleramide and its derivatives

Stereoselective total synthesis of (-)-kunstleramide, a cytotoxic dienamide from the bark of Beilschmiedia kunstleri gamble, has been accomplished by using Keck's asymmetric allylation and Trost isomerization as key reactions. Application of the developed strategy for the synthesis of a series of amide analogues (8-22) was also reported. Furthermore, the synthesized compounds were evaluated for their in vitro anti-proliferative activities against human epithelial lung carcinoma (A549), human epithelial cervical cancer (HeLa), human breast adenocarcinoma (MCF7) and human neuroblastoma (IMR32) cell lines using the SRB assay. All the compounds show moderate anti-proliferative activity against all cell lines. Some of the piperazine derivatives (17-22) strongly inhibit the growth of breast cancer cells with IC50 values of 8-20 μM.