1448902-71-3Relevant articles and documents
Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5- oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
Mori, Yutaka,Ogawa, Yasuyuki,Mochizuki, Akiyoshi,Nakamura, Yuji,Sugita, Chie,Miyazaki, Shojiro,Tamaki, Kazuhiko,Matsui, Yumi,Takahashi, Mizuki,Nagayama, Takahiro,Nagai, Yoko,Inoue, Shin-Ichi,Nishi, Takahide
, p. 7677 - 7682 (2013/02/21)
Utilizing X-ray crystal structure analysis, (3S,5R)-5-[4-(2-chlorophenyl)- 2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides were designed and identified as renin inhibitors. The most potent compound 15 demonstrated favorable pharmacokinetic and
