144891-25-8

Basic information

• Product Name: 1,3-Difluoro-5-ethoxybenzene
• Synonyms: 1,3-Difluoro-5-ethoxybenzene
• CAS NO: 144891-25-8
• Molecular Weight: 158.148
• Mol File: 144891-25-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,3-Difluoro-5-ethoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Difluoro-5-ethoxybenzene(144891-25-8)
• EPA Substance Registry System: 1,3-Difluoro-5-ethoxybenzene(144891-25-8)

Safety Data

• Hazardous Substances Data: 144891-25-8(Hazardous Substances Data)

Usage

Functional groups

Fluoroether (contains fluorine and ether functional groups)

Physical state

Colorless liquid at room temperature

Odor

Strong, sweet

Industrial applications

Intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds

Additional uses

Solvent and in organic synthesis

Acute toxicity

Low to moderate

Health hazards

Can cause irritation to skin, eyes, and respiratory system if exposed to high levels

Precaution

Handle with care due to potential health risks

Upstream product

• 74-96-4 ethyl bromide 
• 2713-34-0 3,5-difluorophenol 
• 75-03-6 ethyl iodide 
• 64-67-5 diethyl sulfate 

Downstream Products

• 916483-56-2 4-ethoxy-2,6-difluorobenzoic acid 
• 1153861-21-2 (4-ethoxy-2,6-difluoro-phenyl)-hydroxy-acetic acid ethyl ester 
• 916483-55-1 tert-butyl (2R)-2-[({4-[(1-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-4-yl)amino]-7-ethoxyquinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate hydrochloride 
• 916483-61-9 5-{[(2R)-1-benzylpyrrolidin-2-yl]methoxy}-7-ethoxyquinazolin-4(3H)-one 
• 916483-57-3 4-ethoxy-2,6-difluorobenzamide 
• 1373920-79-6 2,6-difluoro-4-ethoxybenzoyl chloride 
• 916483-58-4 4-ethoxy-2,6-difluorobenzonitrile 
• 916483-59-5 2-amino-4-ethoxy-6-fluorobenzonitrile 

Relevant articles and documents

A 1- alkoxyl fluorinegeneration of benzene apperception composition preparation method

The invention relates to a preparation method for a 1-(alkoxy)fluorobenzene compound. The method includes the steps of making fluorophenol and inorganic bases react to generate base metal salt of fluorophenol; secondly, dropwise adding haloalkane to generate 1-(alkoxy)fluorobenzene and salt. The method is simple in process and convenient to operate, the obtained product is high in purity, yield is high, the environment pollution is small, and the method is suitable for large-scale industrial production.

METHYL-BENZIMIDAZOLE DERIVATIVES

The invention is concerned with novel substituted benzimidazole derivatives of formula (I) wherein R1 to R10 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds can be used as medicaments.

QUINAZOLINES AND THEIR USE AS AURORA KINASE INHIBITORS

The invention provided a compound of formula (I) for use in the treatment of disease, in particular proliferative diseases such as cancer and for use in the preparation of medicaments for use in the treatment of proliferative diseases; the invention also