1449389-89-2

Basic information

• Product Name: 1-benzyl-4-(naphthalen-2-yl)-2-phenyl-1H-imidazole
• Synonyms: 1-benzyl-4-(naphthalen-2-yl)-2-phenyl-1H-imidazole
• CAS NO: 1449389-89-2
• Molecular Weight: 360.458
• Mol File: 1449389-89-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-benzyl-4-(naphthalen-2-yl)-2-phenyl-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-(naphthalen-2-yl)-2-phenyl-1H-imidazole(1449389-89-2)
• EPA Substance Registry System: 1-benzyl-4-(naphthalen-2-yl)-2-phenyl-1H-imidazole(1449389-89-2)

Safety Data

• Hazardous Substances Data: 1449389-89-2(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 177750-24-2 N-(1-(naphthalen-2-yl)vinyl)acetamide 
• 93-08-3 methyl 2-naphthyl ketone 

Relevant articles and documents

Electrochemical HI-mediated Intermolecular C-N Bond Formation to Synthesize Imidazoles from Aryl Ketones and Benzylamines

An efficient and novel electrochemical oxidative tandem cyclization of aryl ketones and benzylamines for the synthesis of 1,2,4-trisubstituted-(1H)-imidazoles has been developed under metal- and oxidant-free conditions. This direct C-N bond formation strategy, with a broad functional group tolerance, affords the desired imidazoles in moderate to excellent yields.

Construction of substituted imidazoles from aryl methyl ketones and benzylamines via N-heterocyclic carbene-catalysis

A novel synthetic strategy for the construction of substituted imidazoles from acetophenones and benzylamines via N-heterocyclic carbene (NHC) - catalysis was reported. This reaction can be performed under solvent-free condition without pre-functionalization of substrates. Various substituted acetophenones and benzylamines were converted to its corresponding imidazoles with good to excellent yields.

Practical synthesis of polysubstituted imidazoles via iodine- Catalyzed aerobic oxidative cyclization of aryl ketones and benzylamines

A practical synthetic method for polysubstituted imidazoles via iodine-catalyzed aerobic oxidative cyclization of aryl ketones and benzylamines has been developed. It was found to tolerate a broad range of substrates to prepare polysubstituted imidazole derivatives in a one-pot manner, and thus importantly allowed product diversity for imidazole chemistry. Additionally, the resultant 1,2,4-trisubstituted imidazoles could be conveniently transformed to functionalized 1,2,4,5-tetrasubstituted imidazoles via electrophilic substitution or direct C-H functionalization, or 2,4-diaryl-1H-imidazoles by debenzylation reaction, which further indicates potential applications of this method in synthetic and pharmaceutical chemistry. Copyright