1449473-81-7

Basic information

• Product Name: 4-(2-((1R,2R)-1-amino-2-methoxypropyl)-1H-benzo[d]imidazol-5-yl)-3-fluorobenzonitrile formate
• Synonyms: 4-(2-((1R,2R)-1-amino-2-methoxypropyl)-1H-benzo[d]imidazol-5-yl)-3-fluorobenzonitrile formate
• CAS NO: 1449473-81-7
• Molecular Weight: 370.383
• Mol File: 1449473-81-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(2-((1R,2R)-1-amino-2-methoxypropyl)-1H-benzo[d]imidazol-5-yl)-3-fluorobenzonitrile formate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-((1R,2R)-1-amino-2-methoxypropyl)-1H-benzo[d]imidazol-5-yl)-3-fluorobenzonitrile formate(1449473-81-7)
• EPA Substance Registry System: 4-(2-((1R,2R)-1-amino-2-methoxypropyl)-1H-benzo[d]imidazol-5-yl)-3-fluorobenzonitrile formate(1449473-81-7)

Safety Data

• Hazardous Substances Data: 1449473-81-7(Hazardous Substances Data)

Upstream product

• 1449475-32-4 tert-butyl ((1R,2R)-1-(5-bromo-1H-benzo[d]imidazol-2-yl)-2-methoxypropyl)carbamate 
• 64-18-6 formic acid 
• 60538-19-4 N-(tert-butoxycarbonyl)-l-threonine methyl ester 
• 48068-25-3 (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-methoxybutanoic acid 
• 4144-02-9 O-methyl-L-threonine 
• 1449476-01-0 tert-butyl ((2S,3R)-1-((2-amino-4-bromophenyl)amino)-3-methoxy-1-oxobutan-2-yl)carbamate 
• 1575-37-7 4-Bromo-benzene-1,2-diamine 

Relevant articles and documents

The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain

The voltage gated sodium channel NaV1.8 has been postulated to play a key role in the transmission of pain signals. Core hopping from our previously reported phenylimidazole leads has allowed the identification of a novel series of benzimidazole NaV1.8 blockers. Subsequent optimization allowed the identification of compound 9, PF-06305591, as a potent, highly selective blocker with an excellent preclinical in vitro ADME and safety profile.