1449500-81-5

Basic information

• Product Name: 6-benzyl-N⁴-butyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-2,4-diamine
• Synonyms: 6-benzyl-N⁴-butyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-2,4-diamine
• CAS NO: 1449500-81-5
• Molecular Weight: 311.43
• Mol File: 1449500-81-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-benzyl-N⁴-butyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-2,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-benzyl-N⁴-butyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-2,4-diamine(1449500-81-5)
• EPA Substance Registry System: 6-benzyl-N⁴-butyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-2,4-diamine(1449500-81-5)

Safety Data

• Hazardous Substances Data: 1449500-81-5(Hazardous Substances Data)

Upstream product

• 1454-53-1 ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride 
• 1029-52-3 2-amino-6-benzyl-5,6,7,8-tetrahydropyrido[4.3-d]pyrimidin-4-ol 
• 570415-48-4 6-benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine 
• 109-73-9 N-butylamine 

Downstream Products

• 1449500-83-7 tert-butyl (6-benzyl-4-((tert-butoxycarbonyl)(butyl)amino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)(tert-butoxycarbonyl)carbamate 

Relevant articles and documents

Design and synthesis of tetrahydropyridopyrimidine based Toll-Like Receptor (TLR) 7/8 dual agonists

In a continuing effort to discover novel TLR agonists, herein we report on the discovery and structure–activity relationship of novel tetrahydropyridopyrimidine TLR 7/8 agonists. Optimization of this series towards dual agonist activity and a high clearance profile resulted in the identification of compound 52a1. Evaluation in vivo revealed an interferon stimulated response (ISG) in mice with limited systemic exposure and demonstrated the potential in antiviral treatment or as a vaccine adjuvant.

PIPERIDINO-PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS

This invention relates to piperidino-pyhmidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.