1449580-83-9

Basic information

• Product Name: 2-(5-fluoro-1H-indol-4-yl)-5-[4-(3,3-dimethylpiperazin-1-yl)phenyl]-1,3-oxazole-4-carboxylic acid amide
• Synonyms: 2-(5-fluoro-1H-indol-4-yl)-5-[4-(3,3-dimethylpiperazin-1-yl)phenyl]-1,3-oxazole-4-carboxylic acid amide
• CAS NO: 1449580-83-9
• Molecular Weight: 433.485
• Mol File: 1449580-83-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(5-fluoro-1H-indol-4-yl)-5-[4-(3,3-dimethylpiperazin-1-yl)phenyl]-1,3-oxazole-4-carboxylic acid amide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-fluoro-1H-indol-4-yl)-5-[4-(3,3-dimethylpiperazin-1-yl)phenyl]-1,3-oxazole-4-carboxylic acid amide(1449580-83-9)
• EPA Substance Registry System: 2-(5-fluoro-1H-indol-4-yl)-5-[4-(3,3-dimethylpiperazin-1-yl)phenyl]-1,3-oxazole-4-carboxylic acid amide(1449580-83-9)

Safety Data

• Hazardous Substances Data: 1449580-83-9(Hazardous Substances Data)

Upstream product

• 1449580-95-3 4-[4-(4-(ethoxycarbonyl)-1,3-oxazol-5-yl)phenyl]-2,2-dimethylpiperazine-1-carboxylic acid tert-butyl ester 
• 1711-02-0 4-iodobenzoic acid chloride 
• 916674-32-3 5-(4-iodophenyl)-1,3-oxazole-4-carboxylic acid ethyl ester 
• 399-52-0 5-fluoro-1H-indole 
• 1093066-71-7 1-(tert-butyldimethylsilanyl)-5-fluoro-1H-indole 
• 1093066-72-8 [1-(tert-butyldimethylsilanyl)-5-fluoro-1H-indol-4-yl]boronic acid 
• 1449581-13-8 4-[4-(4-carboxy-1,3-oxazol-5-yl)phenyl]-2,2-dimethylpiperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

AURORA AND FLT3 KINASES MODULATORS

The invention provides a compound having the formula (1): and salts thereof; wherein: R1 is hydrogen or C1-2 alkyl; and R2, R3 and R4 are the same or different and each is selected from hydrogen, C1-2 alkyl, fluorine, chlorine, C1-2 alkoxy and trifluoromethyl, provided that no more than two of R2, R3 and R4 are other than hydrogen. Also provided are pharmaceutical compositions containing the compounds and their use in medicine, and in particular in the treatment of cancer.