14496-34-5Relevant articles and documents
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Weilmuenster,Jordan
, p. 415 (1945)
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Simplified preparation of a graphene-co-shelled Ni/NiO@C nano-catalyst and its application in theN-dimethylation synthesis of amines under mild conditions
Liu, Jianguo,Ma, Longlong,Song, Yanpei,Zhang, Mingyue,Zhuang, Xiuzheng
supporting information, p. 4604 - 4617 (2021/06/30)
The development of Earth-abundant, reusable and non-toxic heterogeneous catalysts to be applied in the pharmaceutical industry for bio-active relevant compound synthesis remains an important goal of general chemical research.N-methylated compounds, as one of the most essential bioactive compounds, have been widely used in the fine and bulk chemical industries for the production of high-value chemicals. Herein, an environmentally friendly and simplified method for the preparation of graphene encapsulated Ni/NiO nanoalloy catalysts (Ni/NiO@C) was developed for the first time, for the highly selective synthesis ofN-methylated compounds using various functional amines and aldehydes under easy to handle, and industrially applicable conditions. A large number of primary and secondary amines (more than 70 examples) could be converted to the correspondingN,N-dimethylamines with the participation of different functional aldehydes, with an average yield of over 95%. A gram-scale synthesis also demonstrated a similar yield when compared with the benchmark test. In addition, it was further proved that the catalyst could easily be recycled because of its intrinsic magnetism and reused up to 10 times without losing its activity and selectivity. Also, for the first time, the tandem synthesis ofN,N-dimethylamine products in a one-pot process, using only a single earth-abundant metal catalyst, whose activity and selectivity were more than 99% and 94%, respectively, for all tested substrates, was developed. Overall, the advantages of this newly developed method include operational simplicity, high stability, easy recyclability, cost-effectiveness of the catalyst, and good functional group compatibility for the synthesis ofN-methylation products as well as the industrially applicable tandem synthesis process.
Method for preparing tertiary amine organic compound by decomposing substituted formamide under mild condition
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Paragraph 0040-0042; 0049, (2021/06/13)
The invention discloses a method for preparing tertiary amine organic compounds by decomposing substituted formamide under mild conditions, which comprises the following steps: heating and stirring aldehydes serving as a reaction substrate, substituted formamide serving as a solvent, a reducing agent and an amination reagent, Ti-based oxide/hydroxide serving as a catalyst and a small amount of water serving as an auxiliary agent to generate the corresponding tertiary amine compound. Hydrogen is not needed in the reaction process. The method can be suitable for various aldehydes including aromatic aldehydes, fatty aldehydes and the like, and has the characteristics of high conversion rate and single product, and the tertiary amine compound can be simply, efficiently and safely synthesized without using hydrogen and noble metals in the reaction, so that the method has remarkable economic effects and application prospects.
Method for preparing tertiary amine organic compounds by using substituted formamide
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Paragraph 0026-0028, (2019/01/24)
The invention discloses a method for preparing tertiary amine organic compounds by using substituted formamide. According to the method, aldehyde is used as a reaction substrate, substituted formamideis used as a solvent, reducing agent and aminating agent, a metal oxide/hydroxide is added as a catalyst, and a small amount of water is added as an auxiliary agent; heating and stirring are carriedout so as to form corresponding tertiary amine compounds; and a reaction can be conducted only through heating without hydrogen and a reducing agent. The method of the invention is applicable to various aldehydes including aromatic aldehydes, fatty aldehydes, etc., and has the characteristics of few by-products and high product yield; and hydrogen is not used in the reaction, and the use of a noble metal hydrogenation catalyst is avoided, so the method has remarkable technical and economic effects and application prospects.