1449698-48-9

Basic information

• Product Name: 2-chloro-3-nitro-5-(trifluoromethyl)benzoyl isothiocyanate
• Synonyms: 2-chloro-3-nitro-5-(trifluoromethyl)benzoyl isothiocyanate
• CAS NO: 1449698-48-9
• Molecular Weight: 310.641
• Mol File: 1449698-48-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-chloro-3-nitro-5-(trifluoromethyl)benzoyl isothiocyanate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-3-nitro-5-(trifluoromethyl)benzoyl isothiocyanate(1449698-48-9)
• EPA Substance Registry System: 2-chloro-3-nitro-5-(trifluoromethyl)benzoyl isothiocyanate(1449698-48-9)

Safety Data

• Hazardous Substances Data: 1449698-48-9(Hazardous Substances Data)

Upstream product

• 22227-59-4 2-chloro-3-nitro-5-(trifluoromethyl)benzoic acid 
• 87033-30-5 2-chloro-3-nitro-5-(trifluoromethyl)benzoyl chloride 
• 1147550-11-5 ammonium thiocyanate 
• 657-06-7 2-chloro-5-trifluoromethylbenzoic acid 

Downstream Products

• 957217-65-1 BTZ043 

Relevant articles and documents

Benzothiazinone derivative with 6-position substituted with trifluoromethyl as well as preparation method and application thereof

The invention discloses a benzothiazinone derivative with the 6-position substituted with trifluoromethyl as well as a preparation method and application of the benzothiazinone derivative. According to the invention, benzene ring of a benzothiazinone framework is creatively changed, particularly a substituent group is creatively changed, a series of compounds are obtained, and unexpected technical effects are achieved; and specifically, compared with other benzothiazinone derivatives, the benzothiazinone derivative with the 6-position substituted with trifluoromethyl is more stable to liver microsomal enzyme, the metabolic half-life period T1/2 is longer, and the water solubility is better.

BENZOTHIAZINETHIONE DERIVATIVES AND PREPARATION METHODS AND USES THEREOF

Benzothiazinethione derivatives of formula (I), their preparative methods and uses are provided. Benzothiazinethione derivatives of the invention have significant effect of inhibiting Mycobacterium tuberculosis.

Synthesis and structure-activity relationships evaluation of benzothiazinone derivatives as potential anti-tubercular agents

N-Alkyl and heterocycle substituted 1,3-benzothiazin-4-one (BTZ) derivatives were synthesized. The anti-mycobacterial activities of these compounds were evaluated by determination of minimal inhibitory concentration (MIC) for Mycobacterium tuberculosis H3