145-42-6 Usage
Description
Sodium taurocholate, a bile salt derived from the liver, is a white to off-white powder. It plays a crucial role in the digestion and absorption of dietary fats by emulsifying them, making them more accessible for enzymatic breakdown. Sodium taurocholate also selectively activates retinoid X receptors (RXRs), which are involved in various cellular processes.
Uses
Used in Pharmaceutical Industry:
Sodium taurocholate is used as a detergent for the solubilization of lipids and membrane-bound proteins. This application is particularly useful in the pharmaceutical industry for the extraction and purification of proteins, as well as for the study of protein-lipid interactions.
Used in Digestive Health:
Sodium taurocholate is used as a therapeutic agent for improving digestive health. It aids in the digestion and absorption of dietary fats by emulsifying them, making them more accessible for enzymatic breakdown. This can be beneficial for individuals with fat malabsorption issues or those requiring support for healthy liver function.
Used in Research and Development:
In the field of research and development, Sodium taurocholate is used as a tool to study the effects of bile salts on various biological processes. Its ability to activate retinoid X receptors (RXRs) makes it a valuable compound for investigating the role of these receptors in cellular signaling and gene regulation.
Used in Drug Delivery Systems:
Sodium taurocholate can be utilized in the development of drug delivery systems, particularly for hydrophobic drugs. Its detergent properties allow for the solubilization of lipids and membrane-bound proteins, which can enhance the bioavailability and efficacy of certain medications.
Purification Methods
Purify it by recrystallisation and gel chromatography using Sephadex LH-20. [Beilstein 10 III 1655, 10 IV 2078.]
Check Digit Verification of cas no
The CAS Registry Mumber 145-42-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 5 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 145-42:
(5*1)+(4*4)+(3*5)+(2*4)+(1*2)=46
46 % 10 = 6
So 145-42-6 is a valid CAS Registry Number.
InChI:InChI=1/C26H45NO7S.Na/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29;/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34);/q;+1/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-;/m1./s1
145-42-6Relevant articles and documents
Synthetic method and medicinal preparation of sodium taurocholate
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Paragraph 0084-0085, (2021/11/03)
The method comprises the following steps: S10, dissolving taurine and a base in water for salt formation reaction, drying the generated salt after the reaction is ended, and obtaining taurine sodium. S20, the taurine sodium and cholic acid are subjected to condensation reaction under 2 - ethoxy -1 - ethoxycarbonyl -1 and 2 - 80 - 120 °C dihydroquinoline, and a product solution containing sodium taurocholate is obtained. S30, sodium taurocholate in the product solution is separated and purified to obtain the sodium taurocholate product. To the method, taurine and a base are subjected to salt formation reaction to obtain sodium taurocholate, and condensation reaction is carried out, so that an existing 'one-pot' is changed into a two-step method. In addition, the synthetic method provided by the invention is simple to operate and low in cost.
Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts
Venturoni, Francesco,Gioiello, Antimo,Sardella, Roccaldo,Natalini, Benedetto,Pellicciari, Roberto
experimental part, p. 4109 - 4115 (2012/06/15)
A multi-gram scale protocol for the N-acyl amidation of bile acids with glycine and taurine has been successfully developed under continuous flow processing conditions. Selecting ursodeoxycholic acid (UDCA) as the model compound and N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) as the condensing agent, a modular mesoreactor assisted flow set-up was employed to significantly speed up the optimization of the reaction conditions and the flow scale-up synthesis. The results in terms of yield, in line purification, analysis, and implemented flow set-up for the reaction optimization and large scale production are reported and discussed.