145012-49-3

Basic information

• Product Name: 2,5-Piperidinedicarboxylic acid, 5-Methyl ester, (2R,5S)-rel-
• Synonyms: 2,5-Piperidinedicarboxylic acid, 5-Methyl ester, (2R,5S)-rel-;(2S,5R)-5-(Methoxycarbonyl)piperidine-2-carboxylic acid;(2R,5S)-rel-5-(Methoxycarbonyl)piperidine-2-carboxylic acid;(2R,5S)-5-(Methoxycarbonyl)piperidine-2-carboxylic acid
• CAS NO: 145012-49-3
• Molecular Formula: C8H13NO4
• Molecular Weight: 187.19312
• Mol File: 145012-49-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,5-Piperidinedicarboxylic acid, 5-Methyl ester, (2R,5S)-rel-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Piperidinedicarboxylic acid, 5-Methyl ester, (2R,5S)-rel-(145012-49-3)
• EPA Substance Registry System: 2,5-Piperidinedicarboxylic acid, 5-Methyl ester, (2R,5S)-rel-(145012-49-3)

Safety Data

• Hazardous Substances Data: 145012-49-3(Hazardous Substances Data)

Usage

Properties

Chemical formula: C9H15NO4
Derivative of piperidine
Used in synthesis of pharmaceuticals and agrochemicals
Potential as a building block in organic synthesis
Stereochemical properties indicated by (2R,5S)-reldesignation
Methyl ester group providing unique properties

Specific content

Molecular formula: C9H15NO4
Derivative of piperidine
Used in synthesis of pharmaceuticals and agrochemicals
Potential building block in organic synthesis, particularly in formation of peptide linkages
Stereochemical properties represented by (2R,5S)-reldesignation
Methyl ester group providing unique properties and potential applications in various industries

Upstream product

• 1346684-88-5 pyridine-2,5-dicarboxylic acid 5-methyl ester hydrogen chloride 
• 881-86-7 dimethyl 2,5-pyridine dicarboxylate 
• 2207-52-5 piperidine-2,5-dicarboxylic acid dimethyl ester 
• 2207-52-5 cis-2,5-Piperidinedicarboxylic acid methyl ester 
• 90-02-8 salicylaldehyde 

Relevant articles and documents

Preparation of differentiated diamides of 4,5,6,7-tetrahydropyrazolo[1,5-a] pyridine-2,6- and -3,6-dicarboxylic acids suitable for parallel synthesis

1,3-Dipolar cycloaddition of a bicyclic sydnone to a propargylic acid amide affords 4,5,6,7-tetra-hydropyrazolo[1,5-a]pyridine-2,6- and -3,6-dicarboxylic acid monoamides which are further converted to corresponding differentiated diamides.

Synthesis of trans-7-Hydroxymethyl-2-(2-benzisoxazol-3-yl)octahydro-2H-pyridopyrazine

An efficient synthesis of trans-7-hydroxymethyl-2-(2-benzisoxazol-3-yl)octahydro-2H-pyridopyrazine 2 is presented which relies on the equilibration of cis-dimethyl piperidinedicarboxylate followed by alkylation with phthalimidoethyl triflate.

Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines

Antipsychotic compounds having the formula STR1 wherein Z is H or Cl; Y is O or S; n is 1-4; separately, X is H or (C1 -C2)alkyl and L is R(CH2)m CO, m is 0 or 1-3, R is (C1 -C6)alkyl, (C3 -C7)cycloalkyl, phenyl, naphthyl, furyl, benzofuranyl, thienyl, benzothienyl, pyrrolyl, indolyl, isoindolyl or one of said groups substituted on aromatic or heteroaromatic ring with fluoro, chloro, (C1 -C2)alkyl or (C1 -C2)alkoxy; or together L and X, in combination with the nitrogen to which they are attached, form certain cyclic imides, 4-substituted piperidines or a cyclic sulfonamide.