145050-29-9Relevant articles and documents
Synthesis of β2-homophenylalanine derivatives by Negishi cross-coupling reactions
Bartrum, Hannah E.,Adams, Harry,Caggiano, Lorenzo,Jackson, Richard F.W.
, p. 3701 - 3712 (2008/09/20)
Three approaches to the synthesis of β2-homophenylalanine derivatives using Negishi cross-coupling reaction are reported. In the first two approaches, two protected α-iodomethyl-β-amino esters are each converted into the corresponding organozinc iodides, which then undergo Pd-catalysed cross-coupling with aromatic halides to give β2-homophenylalanine derivatives, and the X-ray crystal structure of one product is reported. Alternatively, Negishi cross-coupling of the zinc reagent derived from N-benzyl 3-iodomethyl azetidin-2-one and aryl halides gave 3-benzylazetidin-2-ones, masked β2-homophenylalanine derivatives. The X-ray crystal structure of 1-benzyl-3-[(p-toluenesulfonyloxy)-methyl]-azetidin-2-one confirms the structural assignment.
New synthesis of α-(1-hydroxy)alkyl-β-lactams
Amri,El Gaied,Ayed,Villieras
, p. 6159 - 6160 (2007/10/02)
Direct condensation of primary amines and ethyl-2-hydroxyalkylacrylates, in methanol at reflux, gave 3-hydroxyalkylazetidin-2-ones in good to fair yields.
