1450833-09-6

Basic information

• Product Name: C₂₂H₄₂N₂O₆
• Synonyms: C₂₂H₄₂N₂O₆
• CAS NO: 1450833-09-6
• Molecular Weight: 430.585
• Mol File: 1450833-09-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₄₂N₂O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₄₂N₂O₆(1450833-09-6)
• EPA Substance Registry System: C₂₂H₄₂N₂O₆(1450833-09-6)

Safety Data

• Hazardous Substances Data: 1450833-09-6(Hazardous Substances Data)

Upstream product

• 69567-11-9 2,3,4,6-tetra-O-benzyl-1,5-dideoxy-1,5-imino-D-glucitol 
• 1450832-96-8 (2R,3R,4R,5S)-1-(4-aminobutyl)-2-(hydroxymethyl)piperidine-3,4,5-triol 
• 94133-41-2 (+)-menthyloxyacetic acid 
• 1450832-95-7 4-((2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)piperidin-1-yl)butan-1-amine 
• 1450832-94-6 2-(4-((2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)piperidin-1-yl)butyl)isoindoline-1,3-dione 

Relevant articles and documents

Rapid modifications of N-substitution in iminosugars: Development of new β-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease

The rapid discovery of β-glucocerebrosidase (GCase) inhibitors and pharmacological chaperones for Gaucher disease is described. The N-aminobutyl DNJ-based iminosugar was synthesized and conjugating with a variety of carboxylic acids to generate a N-diversely substituted iminosugar-based library. Several members of this library were found to be nanomolar-range inhibitors of GCase; the inhibition constant Ki of the most potent was found to be 71 nM. Although these new molecules showed reasonable chaperoning activity (1.5- to 1.9-fold) in the N370S fibroblast of Gaucher patient-derived cell line, this was accompanies by a concomitant decrease in the cellular α-glucosidase activity, which might limit their further therapeutic potential. Next, newly developed N-substituents were assembled with pyrrolidine-based scaffolds to generate new molecules for further evaluation. The new 2,5-dideoxy-2,5-imino-d- mannitol (DMDP)-based iminosugar 22 was found to exhibit a satisfactory chaperoning activity to enhance GCase activity by 2.2-fold in Gaucher N370S cell line, without impairment of cellular α-glucosidase activity.