145084-28-2

Basic information

• Product Name: (R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA
• Synonyms: (R)-N-(2,3-Dihydro-1-(2-(2-methylphenyl)-2-oxoethyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-N'-(3-methylphenyl)urea;N-[(3R)-2,3-Dihydro-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N′-(3-methylphenyl)-urea;(R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA;YM 022
• CAS NO: 145084-28-2
• Molecular Formula: C32H28N4O3
• Molecular Weight: 516.59
• Product Categories: Cholecystokinin (CCK) receptor
• Mol File: 145084-28-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 735.4°Cat760mmHg
• Flash Point: 398.6°C
• Appearance: white to beige/
• Density: 1.23g/cm³
• Storage Temp.: Store at RT
• Solubility: DMSO: soluble5mg/mL (clear solution)
• CAS DataBase Reference: (R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA(145084-28-2)
• EPA Substance Registry System: (R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA(145084-28-2)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 145084-28-2(Hazardous Substances Data)

Usage

Description

(R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA, also known as YM 022, is a potent and selective non-peptide antagonist of the gastrin/cholecystokinin (CCK)-B receptor. It exhibits high affinity for the CCK-B receptor with Ki values of 68 pM and 63 nM at CCK2 and CCK1 receptors, respectively. (R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOETHYL]-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPIN-3-YL]-N'-(3-METHYLPHENYL)-UREA plays a significant role in various applications due to its receptor antagonist properties.

Uses

Used in Pharmaceutical Industry:
YM 022 is used as a pharmacological agent for targeting the gastrin/cholecystokinin (CCK)-B receptor. Its high selectivity and potency make it a valuable tool in the development of drugs aimed at treating conditions related to the overactivation of the CCK-B receptor, such as certain gastrointestinal disorders and potentially cancer-related conditions.
Used in Research Applications:
In the field of research, YM 022 serves as a valuable compound for studying the role of the CCK-B receptor in various physiological processes and disease states. Its use as a selective antagonist allows researchers to investigate the specific functions and pathways associated with the CCK-B receptor, contributing to a deeper understanding of its role in health and disease.
Used in Drug Development:
YM 022 is utilized in the development of new drugs targeting the CCK-B receptor. Its high affinity and selectivity make it an attractive starting point for the design and synthesis of novel therapeutic agents. These drugs may have potential applications in treating a range of conditions, including gastrointestinal disorders and possibly certain types of cancer.

Biological Activity

Extremely potent and highly selective non-peptide CCK 2 silent antagonist (K i values are 68 pM and 63 nM at CCK 2 and CCK 1 receptors respectively). Acts in vivo to potently inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation with a long duration of action.

Upstream product

• 621-29-4 3-tolyl isocyanate 
• 145084-42-0 (RS)-3-amino-1,3-dihydro-1-(2-methylphenacyl)-5-phenyl-2H-1,4-benzodiazepin-2-one 
• 51012-65-8 2-bromo-1-o-tolylethanone 
• 145084-43-1 1,3-dihydro-1-(2'-methylphenacyl)-5-phenyl-2H-1,4-benzodiazepin-2-one 
• 145084-44-2 1-(2-Oxo-2-o-tolyl-ethyl)-5-phenyl-1H-benzo[e][1,4]diazepine-2,3-dione 3-oxime 
• 2898-08-0 2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one 
• 145084-89-5 (S)-3-amino-1,3-dihydro-1-(2-methylphenacyl)-5-phenyl-2H-1,4-benzodiazepin-2-one 
• 145084-87-3 (R)-3-amino-1,3-dihydro-1-(2-methylphenacyl)-5-phenyl-2H-1,4-benzodiazepin-2-one 

Relevant articles and documents

Benzodiazepine aryl urea derivatives

This invention relates to novel benzodiazepine derivatives represented by the following general formula (I) or pharmaceutically acceptable salts thereof, STR1 (wherein R 1 is an aryl group, or an aromatic heterocyclic radical of 5-membered monocyclic, 6-m