14510-36-2

Basic information

• Product Name: a-((Acetyloxy)methyl)benzeneaceticacid
• Synonyms: a-((Acetyloxy)methyl)benzeneaceticacid;α-[(Acetyloxy)methyl]benzeneacetic acid;3-Acetoxy-2-phenylpropanoic Acid;2-Phenyl-β-acetoxypropanoic Acid;Tropic Acid Acetate
• CAS NO: 14510-36-2
• Molecular Formula: C₁₁H₁₂O₄
• Molecular Weight: 208.2106
• Product Categories: Aromatics;Intermediates;Intermediate in the synthesis of Tropine and respective derivatives
• Mol File: 14510-36-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 348.201 °C at 760 mmHg
• Flash Point: 135.146 °C
• Appearance: /
• Density: 1.22 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: a-((Acetyloxy)methyl)benzeneaceticacid(CAS DataBase Reference)
• NIST Chemistry Reference: a-((Acetyloxy)methyl)benzeneaceticacid(14510-36-2)
• EPA Substance Registry System: a-((Acetyloxy)methyl)benzeneaceticacid(14510-36-2)

Safety Data

• Hazardous Substances Data: 14510-36-2(Hazardous Substances Data)

Usage

Description

a-((Acetyloxy)methyl)benzeneacetic acid, also known as a-((Acetyloxy)methyl)benzeneacetic acid, is an organic compound with the chemical formula C10H10O4. It is a white solid that serves as an intermediate in the synthesis of various organic compounds, particularly tropine and its derivatives. Its chemical structure allows for further functionalization and modification, making it a versatile building block in organic chemistry.

Uses

Used in Pharmaceutical Industry:
a-((Acetyloxy)methyl)benzeneacetic acid is used as an intermediate in the synthesis of tropine and its derivatives, which are important compounds in the pharmaceutical industry. Tropine, an alkaloid found in plants, is a key component in the production of various drugs, including atropine, scopolamine, and hyoscyamine. These drugs have applications in treating conditions such as asthma, peptic ulcers, and Parkinson's disease.
Used in Chemical Synthesis:
a-((Acetyloxy)methyl)benzeneacetic acid is used as a versatile intermediate in the synthesis of various organic compounds. Its chemical properties, including the presence of an acetyloxymethyl group and a carboxylic acid functional group, allow for further reactions and modifications, making it a valuable building block in organic chemistry. This enables the production of a wide range of compounds with diverse applications in various industries, such as agriculture, materials science, and pharmaceuticals.
Used in Research and Development:
Due to its unique chemical structure and reactivity, a-((Acetyloxy)methyl)benzeneacetic acid is also used in research and development for the exploration of new synthetic pathways and the development of novel compounds with potential applications in various fields. Researchers can utilize this intermediate to design and synthesize new molecules with specific properties and functions, contributing to the advancement of science and technology.

Upstream product

• 529-64-6 Tropic acid 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 1570-95-2 2-phenylpropane-1, 3-diol 
• 126986-28-5 3-acetoxy-2-phenyl propanol 
• 103-82-2 phenylacetic acid 
• 590-97-6 acetoxymethyl bromide 

Downstream Products

• 39755-33-4 tropic acid-(2-diethylamino-ethyl ester) 
• 10139-28-3 3-hydroxy-2-phenyl-propionic acid nortropan-3-yl ester 
• 83454-31-3 atropine 
• 1071752-46-9 N-Methylgranatolin-tropasaeure-ester 
• 111295-08-0 atropine 
• 492-38-6 2-phenylacrylic acid 
• 33942-00-6 1-acetoxy-2-chloro-2-phenylethane 
• 529-64-6 Tropic acid 
• 51-34-3 (+/-)-scopolamine 
• 14510-37-3 3-acetoxy-2-phenyl-propionyl chloride 
• 87767-94-0 2-bromo-2-phenylethyl acetate 

Relevant articles and documents

N- Ethylpyridine methylamine hydrochloride and crystal, preparation process and application thereof

The invention discloses N -ethyl-pyridine methylamine trifluoroacetate, and a crystal. preparation process and application N - thereof to prepare N -ethylpyridine methylamine hydrochloride crystals, by slowly adding X -ethyl-pyridine methylamine, in an organic solvent 15.12 °, 15.45 °, 17.68 °, 20.68 °, 22.62 °, 23.25 °, 24.75 °, 29.54 ° at room temperature or heating. to fully dissolve N -ethyl-pyridine methylamine . through heating for, hours to prepare the ethyl-pyridine methylamine trifluoroacetate crystals . The method is simple in operation and;% in crystal form impurity content, obtained by dry-adding trifluoroacetic acid; crystals, at about, at room temperature or, in a heating mode of heating the crystals at a temperature ranging from, N - degrees, to a. material completely-dissolving solution.

Synthesis method of atropine and atropine sulfate

The invention provides a synthesis method of atropine and atropine sulfate, which comprises the following steps: carrying out acetylation reaction on tropine acid to form acetyl tropine acid, reactingthe acetyl tropine acid with a chlorination reagent to form acyl chloride, reacting the acyl chloride with tropine alcohol, removing acetyl to obtain atropine, and salifying atropine and sulfuric acid to obtain atropine sulfate. The whole synthesis process can be completed by adopting a one-pot reaction, additional steps for completing the process by isolating intermediates are avoided, the reaction conditions are mild, the steps are simple, the yield is high, the purity is high, and the method is suitable for large-scale industrial production.

PhSO2SCF2H: A Shelf-Stable, Easily Scalable Reagent for Radical Difluoromethylthiolation

A new shelf-stable and easily scalable difluoromethylthiolating reagent S-(difluoromethyl) benzenesulfonothioate (PhSO2SCF2H) was developed. PhSO2SCF2H is a powerful reagent for radical difluoromethylthiolation of aryl and alkyl boronic acids, decarboxylative difluoromethylthiolation of aliphatic acids, and a phenylsulfonyl-difluoromethylthio difunctionalization of alkenes under mild reaction conditions.