145100-59-0

Basic information

• Product Name: 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-2-propyl-4-[[(trifluoromethyl)sulfonyl]oxy]-, phenylmethyl ester
• CAS NO: 145100-59-0
• Molecular Formula: C17H20F3NO5S
• Molecular Weight: 407.411
• Mol File: 145100-59-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-2-propyl-4-[[(trifluoromethyl)sulfonyl]oxy]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-2-propyl-4-[[(trifluoromethyl)sulfonyl]oxy]-, phenylmethyl ester(145100-59-0)
• EPA Substance Registry System: 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-2-propyl-4-[[(trifluoromethyl)sulfonyl]oxy]-, phenylmethyl ester(145100-59-0)

Safety Data

• Hazardous Substances Data: 145100-59-0(Hazardous Substances Data)

Upstream product

• 145100-51-2 N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide 
• 145100-54-5 benzyl 4-oxo-2-propyl-3,4-dihydropyridine-1(2H)-carboxylate 

Relevant articles and documents

Thermodynamic equilibration of dihydropyridone enolates: application to the total synthesis of (+/-)-epiuleine

Following 1,4-reduction of 2-substituted dihydropyridones (1), the requisite 'kinetic' enolate can be isomerized upon warming to allow the isolation of the thermodynamic enolate as its vinyl triflate (3). This enolate interconversion is dependent on the dihydropyridone C-2 substituent and can be interpreted in terms of conformational analysis. This novel scaffold (3) opens another avenue for the strategic deployment of dihydropyridones into both natural product synthesis and drug discovery. To this end, this method is highlighted by its use as a key step in a total synthesis of (+/-)-epiuleine (14).