145106-47-4

Basic information

• Product Name: (2-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: (2-Oxocyclohexyl)carbamic acid tert-butyl ester;(S)-tert-butyl 2-oxocyclohexylcarbamate;(S)-N-Boc-2-aMinocyclohexanone;S-(2-Oxocyclohexyl)carbamic acid tert-butyl ester
• CAS NO: 145106-47-4
• Molecular Formula: C₁₁H₁₉NO₃
• Molecular Weight: 213.27
• Mol File: 145106-47-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 335.9°C at 760 mmHg
• Flash Point: 157°C
• Appearance: /
• Density: 1.06g/cm³
• Vapor Pressure: 0.000116mmHg at 25°C
• Refractive Index: 1.474
• Storage Temp.: 2-8°C
• PKA: 11.18±0.20(Predicted)
• CAS DataBase Reference: (2-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER(145106-47-4)
• EPA Substance Registry System: (2-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER(145106-47-4)

Safety Data

• Hazardous Substances Data: 145106-47-4(Hazardous Substances Data)

Usage

General Description

"(2-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER" is a chemical compound with the molecular formula C11H19NO3. It is commonly used as a reagent in organic synthesis and pharmaceutical research. The compound is an ester derivative of (2-oxocyclohexyl)carbamic acid, and its tert-butyl ester group provides stability and protection to the molecule. It is a white, crystalline solid at room temperature and is commonly used as a precursor in the synthesis of various pharmaceuticals and biologically active compounds. The compound is also known for its potential application in the field of medicinal chemistry, particularly in drug discovery and development.

InChI:InChI=1/C11H19NO3/c1-11(2,3)15-10(14)12-8-6-4-5-7-9(8)13/h8H,4-7H2,1-3H3,(H,12,14)

Upstream product

• 121282-70-0 (1S,2S)-2-tert-Butoxycarbonylamino-1-cyclohexanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 931-15-7 (1S,2S)-trans-2-aminocyclohexanol 

Downstream Products

• 1382465-51-1 (S)-2-amino-cyclohexanone-(E)-O-methyl-oxime hydrochloride 
• 1382465-22-6 4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid {(S)-2-[(E)-methoxyimino]-cyclohexyl}-amide 
• 1382465-23-7 6-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid {(S)-2-[(E)-methoxyimino]-cyclohexyl}-amide 

Relevant articles and documents

COMPOUNDS, COMPOSITIONS AND METHODS FOR SYNTHESIS

The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.