1451454-53-7Relevant articles and documents
Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones
Doherty, William,James, Jinju,Evans, Paul,Martin, Laura,Adler, Nikoletta,Nolan, Derek,Knox, Andrew
, p. 7561 - 7571 (2015/01/09)
An improved, Weinreb amide-based, synthesis of anti-trypanosomal lysine-containing vinyl sulfones is described incorporating, as a feature, diversity at the ε-lysine amino group. Members of this family demonstrated moderate to good efficacy as anti-trypanosomal agents and a fluorescent dansyl (19) derivative was used to investigate subcellular localisation of the compound class.