145160-37-8

Basic information

• Product Name: 2,4-Dibenzyl-2H-isoquinolin-1-one
• CAS NO: 145160-37-8
• Molecular Weight: 325.41
• Mol File: 145160-37-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,4-Dibenzyl-2H-isoquinolin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dibenzyl-2H-isoquinolin-1-one(145160-37-8)
• EPA Substance Registry System: 2,4-Dibenzyl-2H-isoquinolin-1-one(145160-37-8)

Safety Data

• Hazardous Substances Data: 145160-37-8(Hazardous Substances Data)

Upstream product

• 569-31-3 meconin 
• 108524-66-9 1-phenyl-N-(2-phenylethylidene)methanamine 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 100-52-7 benzaldehyde 
• 59168-21-7 2-benzyl-1-(2H)-isoquinoline ketone 
• 100-39-0 benzyl bromide 

Relevant articles and documents

Investigations concerning the benzylation of tetrahydroisoquinolines with benzaldehyde and substituted benzaldehyde (Rugheimer-Burrows-reaction)

The condensation of piperidine and tetrahydroisoquinoline derivatives with benzaldehyde leading to the corresponding benzylated aromatic systems is a multistep reaction for which different mechanisms are discussed. Isolation and characterization of the following intermediates and side products are helpful to explain parts of the sequence.