145222-40-8

Basic information

• Product Name: 4-(p-methoxybenzyloxy)-1-hydroxy-2-butyne
• Synonyms: 4-(p-methoxybenzyloxy)-1-hydroxy-2-butyne
• CAS NO: 145222-40-8
• Molecular Weight: 206.241
• Mol File: 145222-40-8.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 4-(p-methoxybenzyloxy)-1-hydroxy-2-butyne(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(p-methoxybenzyloxy)-1-hydroxy-2-butyne(145222-40-8)
• EPA Substance Registry System: 4-(p-methoxybenzyloxy)-1-hydroxy-2-butyne(145222-40-8)

Safety Data

• Hazardous Substances Data: 145222-40-8(Hazardous Substances Data)

Upstream product

• 110-65-6 1,4-dihydroxybut-2-yne 
• 824-94-2 p-methoxybenzyl chloride 
• 50-00-0 formaldehyd 
• 4039-83-2 3-(4-methoxybenzyloxy)propyne 
• 105-13-5 4-Methoxybenzyl alcohol 
• 143833-81-2 (Z)-4-(4-methoxybenzyloxy)but-2-en-1-ol 
• 2746-25-0 p-Methoxybenzyl bromide 
• 207795-41-3 ethyl 4-(4-methoxybenzyloxy)but-2-ynoate 

Downstream Products

• 902168-69-8 (E)-(R)-1-(4-Methoxy-benzyloxy)-hex-3-en-5-yn-2-ol 
• 902168-70-1 1-Methoxy-4-((E)-(R)-2-methoxymethoxy-hex-3-en-5-ynyloxymethyl)-benzene 
• 902168-68-7 (E)-ethyl 3-((2R,3R)-3-((4-methoxybenzyloxy)methyl)oxiran-2-yl)acrylate 
• 863222-52-0 ((2R,3R)-3-((4-methoxybenzyloxy)methyl)oxiran-2-yl)methanol 
• 863222-53-1 (2R,3R)-2,3-epoxy-1-(4-methoxybenzyloxy)-4-pentene 
• 725715-24-2 (S)-1-((4-methoxybenzyl)oxy)pent-4-en-2-ol 
• 199658-06-5 ((2S,3S)-3-((4-methoxybenzyloxy)methyl)oxiran-2-yl)methanol 
• 842125-04-6 (E)-4-((4-methoxybenzyl)oxy)but-2-en-1-al 
• 409064-73-9 C₁₂H₁₆O₃ 

Relevant articles and documents

Novel One-Pot Synthetic Method for Propargyl Alcohol Derivatives from Allyl Alcohol Derivatives

An efficient one-pot procedure for the synthesis of propargyl alcohol derivatives from allyl alcohol derivatives has been developed. The key to this transformation from a C-C double bond to a C-C triple bond is that hydrogen bromide elimination from 1,2-dibromoalkanes that contain a neighboring oxygen functional group is promoted by the inductive electron-withdrawing effect of the oxygen functional group. In the one-pot reaction, tetrabutylammonium hydroxide was the best base, and the addition of molecular sieves 13X also promoted the reaction.

TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE

The present disclosure relates to bifunctional compounds, which find utility as modulators of tan protein. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a VHL or cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds tan protein, such that tan protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of tan. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of tan protein. Diseases or disorders that result from aggregation or accumulation of tan protein are treated or prevented with compounds and compositions of the present disclosure.

TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE

The present disclosure relates to bifunctional compounds, which find utility as modulators of tau protein. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a VHL or cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds tau protein, such that tau protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of tau. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of tau protein. Diseases or disorders that result from aggregation or accumulation of tau protein are treated or prevented with compounds and compositions of the present disclosure.