145226-16-0Relevant articles and documents
A New Synthesis of N-Substituted-2-alkyl(or aryl)quinazolin-4-amines by Amide Base-Mediated Cyclization of Carboximidamides Derived from 2-(Trifluoromethyl)benzenamine
Patterson, Steven E.,Janda, Lubomir,Strekowski, Lucjan
, p. 703 - 706 (2007/10/02)
A one-pot preparation carboximidamides (amidines) 11-14 involves treatment of amides 2-5 with phosphorus pentachloride followed by the treatment of the resultant crude imidoyl chlorides 7-10 with ammonia.Amidines 11-14 are cyclized to quinazolines 20-26 i