145231-33-0

Basic information

• Product Name: S-<3-(4(5)-imidazolyl)propyl>-N-(3-phenylpropyl)isothiourea dihydrobromide
• CAS NO: 145231-33-0
• Molecular Weight: 383.355
• Mol File: 145231-33-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: S-<3-(4(5)-imidazolyl)propyl>-N-(3-phenylpropyl)isothiourea dihydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: S-<3-(4(5)-imidazolyl)propyl>-N-(3-phenylpropyl)isothiourea dihydrobromide(145231-33-0)
• EPA Substance Registry System: S-<3-(4(5)-imidazolyl)propyl>-N-(3-phenylpropyl)isothiourea dihydrobromide(145231-33-0)

Safety Data

• Hazardous Substances Data: 145231-33-0(Hazardous Substances Data)

Upstream product

• 145383-01-3 N-((3-phenylpropyl)carbamothioyl)benzamide 
• 2038-57-5 3-Phenylpropan-1-amine 
• 93168-20-8 N-(3-Phenylpropyl)thiourea 
• 52237-36-2 4-(3-bromopropyl)-1H-imidazole hydrobromide 

Relevant articles and documents

Isothiourea analogues of histamine as potent agonists or antagonists of the histamine H3-receptor

The synthesis and H3-activity of a series of isothiourea analogues of histamine have been described. It has been shown that S-[2-(4(5)-imidazolyl)ethylisothiourea (VUF 8325) is a potent H3-agonist measured as the electrically evoked contraction of the guinea-pig ileum. Upon methylation of the imidazole system or the isothiourea moiety a decrease in affinity was observed leading to either weak agonists or weak antagonists. Introduction of N-(phenylalkyl) substituents at the isothiourea part gives rise to highly potent H3-antagonists. Particularly the 4-chlorobenzyl group appeared to be favourable in the series described resulting in a histamine H3-antagonist with a pA2-value of 9.9.