1452386-56-9

Basic information

• Product Name: 2-(2-bromophenyl)-6-chloro-1-methyl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one
• Synonyms: 2-(2-bromophenyl)-6-chloro-1-methyl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one
• CAS NO: 1452386-56-9
• Molecular Weight: 442.742
• Mol File: 1452386-56-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-bromophenyl)-6-chloro-1-methyl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-bromophenyl)-6-chloro-1-methyl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one(1452386-56-9)
• EPA Substance Registry System: 2-(2-bromophenyl)-6-chloro-1-methyl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one(1452386-56-9)

Safety Data

• Hazardous Substances Data: 1452386-56-9(Hazardous Substances Data)

Upstream product

• 100-63-0 phenylhydrazine 
• 14529-12-5 6-chloro-N-methylisatoic anhydride 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 1452386-67-2 5-(tert-butylimino)-10-chloro-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one 
• 1452386-68-3 10-chloro-5-(cyclohexylimino)-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one 

Relevant articles and documents

A practical, ligand-free, palladium-catalyzed isocyanide insertion reaction for the construction of novel ring-fused quinazolinones

A high-yielding, ligand-free, palladium-catalyzed isocyanide insertion reaction for the synthesis of phthalazino[1,2-b]quinazolinones from the readily obtainable quinazolinones has been developed. Easily handled and relatively low-cost palladium(II) acetate was used as the catalyst, without an additional ligand. Preparation of the quinazolinones involved the cascade reaction of isatoic anhydrides, phenylhydrazines and 2-bromobenzaldehyde catalyzed by p-toluenesulfonic acid in one pot. This novel protocol may be applicable for the synthesis of other important ring-fused heterocyclic compounds. Georg Thieme Verlag Stuttgart. New York.